ML297 [Ligand Id: 7768] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2409106 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kir3.2/Kir3.1/Kir3.1/Kir3.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038489] [GtoPdb: 435, 434] [UniProtKB: P48051, P48549] | ||||||||
| GtoPdb | - | - | 6.7 | pEC50 | 190 | nM | EC50 | ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by thallium flux assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4562-4566 [PMID:23838260] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by cell-based thallium flux assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by thallium-flux based assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 5102-5106 [PMID:25264075] |
| Kir3.4/Kir3.1/Kir3.1/Kir3.4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038488] [GtoPdb: 437, 434] [UniProtKB: P48544, P48549] | ||||||||
| ChEMBL | Activation of GIRK1/4 (unknown origin) | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4562-4566 [PMID:23838260] |
| ChEMBL | Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| ChEMBL | Activation of GIRK1/4 (unknown origin) by thallium-flux based assay | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 5102-5106 [PMID:25264075] |
| GtoPdb | - | - | 6.7 | pEC50 | 190 | nM | EC50 | ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
