ML297 [Ligand Id: 7768] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2409106 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kir3.2/Kir3.1/Kir3.1/Kir3.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038489] [GtoPdb: 435, 434] [UniProtKB: P48051, P48549] | ||||||||
| GtoPdb | - | - | 6.7 | pEC50 | 190 | nM | EC50 | ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by thallium flux assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4562-4566 [PMID:23838260] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by cell-based thallium flux assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| ChEMBL | Activation of GIRK1/2 (unknown origin) by thallium-flux based assay | B | 6.8 | pEC50 | 160 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 5102-5106 [PMID:25264075] |
| Kir3.4/Kir3.1/Kir3.1/Kir3.4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038488] [GtoPdb: 437, 434] [UniProtKB: P48544, P48549] | ||||||||
| ChEMBL | Activation of GIRK1/4 (unknown origin) | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4562-4566 [PMID:23838260] |
| ChEMBL | Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5195-5198 [PMID:23916258] |
| ChEMBL | Activation of GIRK1/4 (unknown origin) by thallium-flux based assay | B | 5.74 | pEC50 | 1800 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 5102-5106 [PMID:25264075] |
| GtoPdb | - | - | 6.7 | pEC50 | 190 | nM | EC50 | ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
