ML297 [Ligand Id: 7768] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2409106
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kir3.2/Kir3.1/Kir3.1/Kir3.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038489] [GtoPdb: 435434] [UniProtKB: P48051P48549]
GtoPdb - - 6.7 pEC50 190 nM EC50 ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969]
ChEMBL Activation of GIRK1/2 (unknown origin) by thallium flux assay B 6.8 pEC50 160 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 4562-4566 [PMID:23838260]
ChEMBL Activation of GIRK1/2 (unknown origin) by cell-based thallium flux assay B 6.8 pEC50 160 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 5195-5198 [PMID:23916258]
ChEMBL Activation of GIRK1/2 (unknown origin) by thallium-flux based assay B 6.8 pEC50 160 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 5102-5106 [PMID:25264075]
Kir3.4/Kir3.1/Kir3.1/Kir3.4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038488] [GtoPdb: 437434] [UniProtKB: P48544P48549]
ChEMBL Activation of GIRK1/4 (unknown origin) B 5.74 pEC50 1800 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 4562-4566 [PMID:23838260]
ChEMBL Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay B 5.74 pEC50 1800 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 5195-5198 [PMID:23916258]
ChEMBL Activation of GIRK1/4 (unknown origin) by thallium-flux based assay B 5.74 pEC50 1800 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 5102-5106 [PMID:25264075]
GtoPdb - - 6.7 pEC50 190 nM EC50 ACS Chem Neurosci (2013) 4: 1278-86 [PMID:23730969]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]