ChEMBL ligand: CHEMBL491 (2-hydroxyflutamide, .alpha.-hydroxyflutamide, Hydroxy-flutamide, Hydroxyflutamide)
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] Androgen receptor/Androgen Receptor in Mouse [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091] Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL	Displacement of [3H]testosterone from wild type human androgen receptor	B	6.37	pKi	430	nM	Ki	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Displacement of [3H]DHT from human androgen receptor in MDA453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1910-1915 [PMID:18291644]
ChEMBL	Inhibition of [3H]DHT binding to androgen receptor of MDA-453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Binding affinity for androgen receptor in human MDA-453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Binding affinity for human androgen receptor transfected into mammalian COS-1 cells	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2000) 10: 411-414 [PMID:10743937]
ChEMBL	Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.	B	7.57	pKi	27	nM	Ki	J Med Chem (1998) 41: 623-639 [PMID:9484511]
ChEMBL	Displacement of [3H]testosterone from human recombinant androgen receptor T877A mutant expressed in LNCaP cells	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Binding affinity for mutant T877A Androgen receptor in human LNCaP cells	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cells	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Displacement of [3H]-DHT from human GST fused AR-LBD (627 to 919 amino acids) transfected in Escherichia coli HB 101 after 15 hrs by liquid scintillation counting assay	B	5.11	pIC50	7690	nM	IC50	Eur J Med Chem (2015) 102: 310-319 [PMID:26295173]
ChEMBL	Displacement of [3H]-DHT from human GST-tagged androgen receptor LBD (627 to 919) expressed in Escherichia coli HB-101 after 15 hrs by liquid scintillation counting analysis	B	5.15	pIC50	7100	nM	IC50	ACS Med Chem Lett (2013) 4: 937-941 [PMID:24900588]
ChEMBL	Antagonist activity at wild type human recombinant androgen receptor assessed as inhibition of testosterone-induced growth of mouse androgen dependent SC3 cells by WST-1 method	F	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2013) 21: 1643-1651 [PMID:23462715]
ChEMBL	Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2020) 63: 10396-10411 [PMID:32847363]
ChEMBL	Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay	B	6.65	pIC50	223.87	nM	IC50	J Med Chem (2012) 55: 6316-6327 [PMID:22746350]
ChEMBL	Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5573-5576 [PMID:17804229]
ChEMBL	Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2007) 15: 174-185 [PMID:17064916]
ChEMBL	Antagonist activity at wild type AR expressed in human SC cells assessed as inhibition of 1 nM DHT-induced cell proliferation after 3 days by WST-8 assay	B	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2015) 102: 310-319 [PMID:26295173]
ChEMBL	Antagonist activity at human androgen receptor expressed in mouse NIH3T3 cells assessed as inhibition of DHT-induced transcriptional activation after 24 hrs by androgen response element-mediated luciferase reporter gene assay	F	7.17	pIC50	67	nM	IC50	Bioorg Med Chem (2008) 16: 8022-8028 [PMID:18707892]
ChEMBL	Inhibitory concentration against human androgen receptor (AR) dependent transcriptional activity in co-transfected mammalian CV-1 cells	F	7.37	pIC50	43	nM	IC50	Bioorg Med Chem Lett (2000) 10: 411-414 [PMID:10743937]
ChEMBL	Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by reporter gene assay	F	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2007) 15: 174-185 [PMID:17064916]
ChEMBL	Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity by reporter gene assay	F	7.51	pIC50	31	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5573-5576 [PMID:17804229]
ChEMBL	Inhibition of androgen receptor in human MDA-453 cells	B	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assay	F	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Antagonist activity at human androgen receptor in MDA453 cells by alkaline phosphatase reporter gene assay	F	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1910-1915 [PMID:18291644]
ChEMBL	Antagonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay	B	7.6	pIC50	25	nM	IC50	J Nat Prod (2009) 72: 1944-1948 [PMID:19863083]
ChEMBL	Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells.	F	7.82	pIC50	15	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]
GtoPdb	-	-	6.6	pEC50	254	nM	EC50	Biochem Pharmacol (1998) 55: 1427-33 [PMID:10076535]
Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
ChEMBL	Antagonist activity at androgen receptor in androgen-dependent mouse SC3 cells assessed as inhibition of testosterone-induced cell growth after 3 days	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2013) 21: 1643-1651 [PMID:23462715]
ChEMBL	Antagonist activity at androgen receptor in mouse SC3 cells assessed as inhibition of DHT-induced cell growth after 3 days by CCK-8/WST-8 assay	B	6.43	pIC50	370	nM	IC50	ACS Med Chem Lett (2013) 4: 937-941 [PMID:24900588]
ChEMBL	In vitro inhibition of DHT (dihydrotestosterone) on proliferation of androgen-sensitive cancer Schionogi (SC-3) cells	F	7.28	pIC50	52	nM	IC50	J Med Chem (1995) 38: 1158-1173 [PMID:7707319]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	In vivo binding affinity for rat ventral prostate androgen receptor by displacement of [3H]R-1881	B	5.68	pKi	2100	nM	Ki	J Med Chem (1992) 35: 1663-1670 [PMID:1588549]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL	Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.	F	5.7	pIC50	2013	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]