ChEMBL ligand: CHEMBL491 (2-hydroxyflutamide, .alpha.-hydroxyflutamide, Hydroxy-flutamide, Hydroxyflutamide)
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] Androgen receptor/Androgen Receptor in Mouse [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091] Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL	Displacement of [3H]testosterone from wild type human androgen receptor	B	6.37	pKi	430	nM	Ki	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Displacement of [3H]DHT from human androgen receptor in MDA453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1910-1915 [PMID:18291644]
ChEMBL	Inhibition of [3H]DHT binding to androgen receptor of MDA-453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Binding affinity for androgen receptor in human MDA-453 cells	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Binding affinity for human androgen receptor transfected into mammalian COS-1 cells	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2000) 10: 411-414 [PMID:10743937]
ChEMBL	Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.	B	7.57	pKi	27	nM	Ki	J Med Chem (1998) 41: 623-639 [PMID:9484511]
ChEMBL	Displacement of [3H]testosterone from human recombinant androgen receptor T877A mutant expressed in LNCaP cells	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Binding affinity for mutant T877A Androgen receptor in human LNCaP cells	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cells	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Displacement of [3H]-DHT from human GST fused AR-LBD (627 to 919 amino acids) transfected in Escherichia coli HB 101 after 15 hrs by liquid scintillation counting assay	B	5.11	pIC50	7690	nM	IC50	Eur J Med Chem (2015) 102: 310-319 [PMID:26295173]
ChEMBL	Displacement of [3H]-DHT from human GST-tagged androgen receptor LBD (627 to 919) expressed in Escherichia coli HB-101 after 15 hrs by liquid scintillation counting analysis	B	5.15	pIC50	7100	nM	IC50	ACS Med Chem Lett (2013) 4: 937-941 [PMID:24900588]
ChEMBL	Antagonist activity at wild type human recombinant androgen receptor assessed as inhibition of testosterone-induced growth of mouse androgen dependent SC3 cells by WST-1 method	F	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2008) 16: 6799-6812 [PMID:18571420]
ChEMBL	Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2013) 21: 1643-1651 [PMID:23462715]
ChEMBL	Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2020) 63: 10396-10411 [PMID:32847363]
ChEMBL	Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay	B	6.65	pIC50	223.87	nM	IC50	J Med Chem (2012) 55: 6316-6327 [PMID:22746350]
ChEMBL	Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5573-5576 [PMID:17804229]
ChEMBL	Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2007) 15: 174-185 [PMID:17064916]
ChEMBL	Antagonist activity at wild type AR expressed in human SC cells assessed as inhibition of 1 nM DHT-induced cell proliferation after 3 days by WST-8 assay	B	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2015) 102: 310-319 [PMID:26295173]
ChEMBL	Antagonist activity at human androgen receptor expressed in mouse NIH3T3 cells assessed as inhibition of DHT-induced transcriptional activation after 24 hrs by androgen response element-mediated luciferase reporter gene assay	F	7.17	pIC50	67	nM	IC50	Bioorg Med Chem (2008) 16: 8022-8028 [PMID:18707892]
ChEMBL	Inhibitory concentration against human androgen receptor (AR) dependent transcriptional activity in co-transfected mammalian CV-1 cells	F	7.37	pIC50	43	nM	IC50	Bioorg Med Chem Lett (2000) 10: 411-414 [PMID:10743937]
ChEMBL	Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by reporter gene assay	F	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2007) 15: 174-185 [PMID:17064916]
ChEMBL	Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity by reporter gene assay	F	7.51	pIC50	31	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5573-5576 [PMID:17804229]
ChEMBL	Inhibition of androgen receptor in human MDA-453 cells	B	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2005) 15: 271-276 [PMID:15603938]
ChEMBL	Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assay	F	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2005) 15: 389-393 [PMID:15603960]
ChEMBL	Antagonist activity at human androgen receptor in MDA453 cells by alkaline phosphatase reporter gene assay	F	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1910-1915 [PMID:18291644]
ChEMBL	Antagonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay	B	7.6	pIC50	25	nM	IC50	J Nat Prod (2009) 72: 1944-1948 [PMID:19863083]
ChEMBL	Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells.	F	7.82	pIC50	15	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]
GtoPdb	-	-	6.6	pEC50	254	nM	EC50	Biochem Pharmacol (1998) 55: 1427-33 [PMID:10076535]
Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
ChEMBL	Antagonist activity at androgen receptor in androgen-dependent mouse SC3 cells assessed as inhibition of testosterone-induced cell growth after 3 days	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2013) 21: 1643-1651 [PMID:23462715]
ChEMBL	Antagonist activity at androgen receptor in mouse SC3 cells assessed as inhibition of DHT-induced cell growth after 3 days by CCK-8/WST-8 assay	B	6.43	pIC50	370	nM	IC50	ACS Med Chem Lett (2013) 4: 937-941 [PMID:24900588]
ChEMBL	In vitro inhibition of DHT (dihydrotestosterone) on proliferation of androgen-sensitive cancer Schionogi (SC-3) cells	F	7.28	pIC50	52	nM	IC50	J Med Chem (1995) 38: 1158-1173 [PMID:7707319]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	In vivo binding affinity for rat ventral prostate androgen receptor by displacement of [3H]R-1881	B	5.68	pKi	2100	nM	Ki	J Med Chem (1992) 35: 1663-1670 [PMID:1588549]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL	Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.	F	5.7	pIC50	2013	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]