compound 21 [PMID: 22802221] [Ligand Id: 6918] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL189568 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4607] [GtoPdb: 35] [UniProtKB: P50052] | ||||||||
| ChEMBL | Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells | B | 8.01 | pKi | 9.8 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 476-479 [PMID:24388688] |
| ChEMBL | Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor | B | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2004) 47: 5995-6008 [PMID:15537354] |
| ChEMBL | Binding affinity to AT2 receptor | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem (2010) 18: 4570-4590 [PMID:20493713] |
| ChEMBL | Binding affinity to AT2 receptor (unknown origin) | B | 9.4 | pKi | 0.4 | nM | Ki | ACS Med Chem Lett (2014) 5: 1129-1132 [PMID:25313325] |
| ChEMBL | Binding affinity to type-2 angiotensin-2 receptor (unknown origin) | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1355-1359 [PMID:26810314] |
| ChEMBL | Binding affinity to AT2 receptor (unknown origin) | B | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2018) 61: 9811-9840 [PMID:29969256] |
| GtoPdb | - | - | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2004) 47: 5995-6008 [PMID:15537354] |
| GtoPdb | - | - | 4.8 | pEC50 | - | - | - | Hypertension (2012) 60: 722-9 [PMID:22802221] |
| AT2 receptor in Rat [GtoPdb: 35] [UniProtKB: P35351] | ||||||||
| GtoPdb | - | - | 5.8 | pEC50 | - | - | - | Hypertension (2012) 60: 722-9 [PMID:22802221] |
| Angiotensin type II receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163122] [UniProtKB: Q2XUH7] | ||||||||
| ChEMBL | Displacement of [125I]angiotensin 2 from AT2 receptor in pig uterus membrane after 1.5 hrs by gamma counting | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem (2010) 18: 4570-4590 [PMID:20493713] |
| ChEMBL | Binding affinity to pig AT2 receptor | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 476-479 [PMID:24388688] |
| AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] | ||||||||
| ChEMBL | Displacement of [125]Ang2 from AT1 receptor in rat liver membrane | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2008) 16: 6841-6849 [PMID:18599297] |
| ChEMBL | Displacement of [125I]-Ang II from AT1 receptor in rat liver membranes after 2 hrs by gamma-counting method | B | 5 | pKi | >10000 | nM | Ki | ACS Med Chem Lett (2015) 6: 178-182 [PMID:25699147] |
| ChEMBL | Displacement of [125I]Ang II from AT1 receptor in rat liver membranes | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2020) 63: 1978-1995 [PMID:32030982] |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Binding affinity to AT1 receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2010) 18: 4570-4590 [PMID:20493713] |
| ChEMBL | Binding affinity to AT1 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 476-479 [PMID:24388688] |
| ChEMBL | Binding affinity to AT1 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | ACS Med Chem Lett (2014) 5: 1129-1132 [PMID:25313325] |
| ChEMBL | Binding affinity to AT1 receptor (unknown origin) | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2018) 61: 9811-9840 [PMID:29969256] |
| Type-1 angiotensin II receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5743] [UniProtKB: P30555] | ||||||||
| ChEMBL | Displacement of [125]Ang2 from AT2 receptor in pig uterus membrane | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem (2008) 16: 6841-6849 [PMID:18599297] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
