succinic acid [Ligand Id: 3637] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL576 (Amber acid, Dihydrofumaric acid, E363, FEMA NO. 4719, NSC-106449, Succinic acid, Succinicum acidum) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9] | ||||||||
| ChEMBL | Binding affinity to human PHD2 by nondenaturing ESI-MS | B | 4 | pKd | >100000 | nM | Kd | J Med Chem (2010) 53: 867-875 [PMID:20025281] |
| ChEMBL | Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature | B | 4 | pKd | >100000 | nM | Kd | J Med Chem (2010) 53: 867-875 [PMID:20025281] |
| ChEMBL | Inhibition of human PHD2 at 293K temperature by solvent relaxation technique | B | 4.07 | pIC50 | 85300 | nM | IC50 | J Med Chem (2010) 53: 867-875 [PMID:20025281] |
| ChEMBL | Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2008) 51: 7053-7056 [PMID:18942826] |
| succinate receptor in Human [GtoPdb: 166] [UniProtKB: Q9BXA5] | ||||||||
| GtoPdb | - | - | 4.7 | pEC50 | 20000 | nM | EC50 |
Nature (2004) 429: 188-93 [PMID:15141213]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
