succinic acid [Ligand Id: 3637] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL576 (E363, Succinic acid)
  • egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
There should be some charts here, you may need to enable JavaScript!
  • succinate receptor in Human [GtoPdb: 166] [UniProtKB: Q9BXA5]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL Binding affinity to human PHD2 by nondenaturing ESI-MS B 4 pKd >100000 nM Kd J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature B 4 pKd >100000 nM Kd J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Inhibition of human PHD2 at 293K temperature by solvent relaxation technique B 4.07 pIC50 85300 nM IC50 J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (2008) 51: 7053-7056 [PMID:18942826]
succinate receptor in Human [GtoPdb: 166] [UniProtKB: Q9BXA5]
GtoPdb - - 4.7 pEC50 20000 nM EC50 Nature (2004) 429: 188-93 [PMID:15141213];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]