Synonyms: Ro 09-1437
Compound class:
Natural product or derivative
Comment: Cyclothialidine is a potent DNA gyrase inhibitor, isolated from Streptomyces filipinensis following microbial broth screening [3]. It belongs to a novel class of antibacterial compounds, containing a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain, that exhibit broad-spectrum in vitro activity against Gram-positive bacteria. Further development of cyclothialidine has been precluded due to low growth-inhibitory activity against intact bacterial cells but analogues with improved in vivo efficacy have been synthesized [1].
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Classification ![]() |
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Compound class | Natural product or derivative |
Synonyms ![]() |
Ro 09-1437 |
Database Links ![]() |
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Specialist databases | |
Antibiotic DB
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860 |
Other databases | |
CAS Registry No. | 147214-63-9 (source: Scifinder) |
ChEBI | CHEBI:29566 |
ChEMBL Ligand | CHEMBL4286501 |
GtoPdb PubChem SID | 405560429 |
PubChem CID | 443601 |
Search Google for chemical match using the InChIKey | HMHQWJDFNVJCHA-ZPGBQQFCSA-N |
Search Google for chemicals with the same backbone | HMHQWJDFNVJCHA |
UniChem Compound Search for chemical match using the InChIKey | HMHQWJDFNVJCHA-ZPGBQQFCSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HMHQWJDFNVJCHA-ZPGBQQFCSA-N |