ChEMBL ligand: CHEMBL433461 (Ro-046790)
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Binding affinity to 5-HT6 receptor (unknown origin)	B	7.24	pKi	58	nM	Ki	Med Chem Res (2005) 14: 1-18
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3214-3216 [PMID:19433358]
ChEMBL	Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells	B	7.26	pKi	55	nM	Ki	J Med Chem (2014) 57: 7160-7181 [PMID:24850589]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 6 receptor	B	7.26	pKi	55	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HEK293 cells	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
ChEMBL	Binding affinity to human 5HT6R	B	7.26	pKi	54.95	nM	Ki	Eur J Med Chem (2017) 135: 117-124 [PMID:28441580]
ChEMBL	Binding affinity against human cloned 5-hydroxytryptamine 6 receptor in HeLa cells using [3H]LSD	B	7.3	pKi	50.12	nM	Ki	J Med Chem (1999) 42: 202-205 [PMID:9925723]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 6 receptor	B	7.3	pKi	50.12	nM	Ki	J Med Chem (2005) 48: 4216-4219 [PMID:15974573]
ChEMBL	Binding affinity to 5HT6 receptor	B	7.3	pKi	50.12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 698-703 [PMID:21190848]
ChEMBL	Displacement of [3H]LSD from human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1719-1721 [PMID:10937732]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting	B	7.33	pKi	47	nM	Ki	J Med Chem (2009) 52: 675-687 [PMID:19159187]
ChEMBL	Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cells	B	7.35	pKi	44.7	nM	Ki	J Med Chem (2005) 48: 1781-1795 [PMID:15771424]
GtoPdb	-	-	7.9	pKi	-	-	-	Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]; Br J Pharmacol (1998) 124: 556-62 [PMID:9647481]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 6 receptor using [3H]- LSD as radioligand	B	7.58	pIC50	26.3	nM	IC50	J Med Chem (2003) 46: 4834-4837 [PMID:14584934]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	7.6	pKi	-	-	-	Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]; Br J Pharmacol (1998) 124: 556-62 [PMID:9647481]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]