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ChEMBL ligand: CHEMBL3417009 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of AChE (unknown origin) | B | 7.8 | pKi | 16 | nM | Ki | Eur J Med Chem (2019) 162: 234-248 [PMID:30447434] |
ChEMBL | Inhibition of human erythrocyte AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate by Ellman' method | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2015) 58: 3172-3187 [PMID:25793650] |
ChEMBL | Mixed type competitive inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every 1 min for 10 mins by Ellman's method | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2018) 158: 463-477 [PMID:30243151] |
ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition by Ellman's method | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2019) 169: 200-223 [PMID:30884327] |
ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and by DTNB reagent based Ellman's method | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (2022) 72: 128873-128873 [PMID:35779827] |
GtoPdb | - | - | 7.8 | pIC50 | 16 | nM | IC50 | Proc Natl Acad Sci USA (2014) 111: E3825-30 [PMID:25157130] |
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
ChEMBL | Inhibition of equine serum BuChE pre-incubated for 5 mins before butyrylthiocholine iodide substrate by Ellman' method | B | 5.45 | pIC50 | 3530 | nM | IC50 | J Med Chem (2015) 58: 3172-3187 [PMID:25793650] |
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] | ||||||||
ChEMBL | Agonist activity at 5-HT4R (unknown origin) | B | 7.98 | pKi | 10.4 | nM | Ki | Eur J Med Chem (2019) 162: 234-248 [PMID:30447434] |
ChEMBL | Displacement of [3H]GR113808 from human 5-HT4 receptor expressed in Chem-1 cell membrane incubated for 60 mins by radiometric scintillation counting analysis | B | 7.98 | pKi | 10.4 | nM | Ki | Bioorg Med Chem Lett (2022) 72: 128873-128873 [PMID:35779827] |
ChEMBL | Displacement of [3H]-GR113808 from recombinant human 5-HT4BR expressed in membranes after 60 mins | B | 8.02 | pKi | 9.5 | nM | Ki | Eur J Med Chem (2019) 162: 234-248 [PMID:30447434] |
ChEMBL | Displacement of [3H]GR113808 from human 5-HT4R membrane in Tris buffer assessed as inhibitory constant measured after 60 mins by filter binding method | B | 8.18 | pKi | 6.6 | nM | Ki | Eur J Med Chem (2019) 169: 200-223 [PMID:30884327] |
ChEMBL | Activity at 5-HT4R (unknown origin) expressed in COS7 cells assessed as increase in sAPPalpha release | B | 7.95 | pEC50 | 11.3 | nM | EC50 | J Med Chem (2015) 58: 3172-3187 [PMID:25793650] |
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
ChEMBL | Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assay | B | 8.18 | pKi | 6.6 | nM | Ki | J Med Chem (2015) 58: 3172-3187 [PMID:25793650] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in human Jurkat cell membranes after 2 hrs by liquid scintillation counting method | B | 7.29 | pKi | 51 | nM | Ki | Eur J Med Chem (2019) 162: 234-248 [PMID:30447434] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]