xeruborbactam [Ligand Id: 13131] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4633785 (Qpx7728, QPX-7728, Xeruborbactam) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta-lactamase OXA-23 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885669] [UniProtKB: Q9L4P2] | ||||||||
| ChEMBL | Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis | B | 9.13 | pKi | 0.74 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
| BlaVIM-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255155] [UniProtKB: Q8GDC1] | ||||||||
| ChEMBL | Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometrically analysis | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
| Class A carbapenemase KPC-2 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5437] [UniProtKB: A8DS27] | ||||||||
| ChEMBL | Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured every 10 secs for 10 mins by spectrophotometric analysis | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (2020) 63: 7491-7507 [PMID:32150407] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
