tetrahydrofolic acid [Ligand Id: 4675] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2021342 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
| ChEMBL | Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 6.52 | pKd | 300 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 6.52 | pKd | 300 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 7.22 | pKd | 60 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| Sclerostin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3580487] [UniProtKB: Q9BQB4] | ||||||||
| ChEMBL | Binding affinity to SOST loop3 (unknown origin) by SPR analysis | B | 7.37 | pKd | 42.43 | nM | Kd | Eur J Med Chem (2024) 271: 116414-116414 [PMID:38677061] |
| ChEMBL | Binding affinity to SOST (unknown origin) by SPR analysis | B | 7.42 | pKd | 37.66 | nM | Kd | Eur J Med Chem (2024) 271: 116414-116414 [PMID:38677061] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
