Synonyms: compound 8 [PMID: 30803745]
Compound class:
Synthetic organic
Comment: TBAJ-587, an analogue of bedaquiline, was discovered at the University of Auckland following a lead optimization programme to identify novel members of the diarylquinolines class of antibacterial compounds [2]. TBAJ-587 has a more favourable ADME profile, lower risk of QT prolongation, and more potent antimycobacterial activity than bedaquiline [2].
See also our entry for TBAJ-876 that was identified in the same study. |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(1S,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoro-3-methoxyphenyl)butan-2-ol |
Synonyms |
compound 8 [PMID: 30803745] |
Database Links | |
Specialist databases | |
Antibiotic DB | TBAJ-587 |
Other databases | |
BindingDB Ligand | 50537220 |
CAS Registry No. | 2252316-16-6 (source: Scifinder) |
ChEMBL Ligand | CHEMBL4529465 |
GtoPdb PubChem SID | 491299842 |
PubChem CID | 138319677 |
Search Google for chemical match using the InChIKey | JJEGOJPMKLRSPJ-POURPWNDSA-N |
Search Google for chemicals with the same backbone | JJEGOJPMKLRSPJ |
UniChem Compound Search for chemical match using the InChIKey | JJEGOJPMKLRSPJ-POURPWNDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JJEGOJPMKLRSPJ-POURPWNDSA-N |