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ChEMBL ligand: CHEMBL88147 (MRS-1220) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.64 | pKi | 231 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Displacement of [3H]-(R)-PIA from Adenosine A1 receptor of rat cerebral cortex membranes | B | 6.52 | pKi | 305 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
ChEMBL | Displacement of specific [3H](R)-PIA binding at adenosine A1 receptor from rat brain membranes. | B | 6.52 | pKi | 305 | nM | Ki | J Med Chem (1997) 40: 2596-2608 [PMID:9258367] |
ChEMBL | Inhibition of [3H]DPCPX binding to rat Adenosine A1 receptor expressed in CHO cells | B | 6.52 | pKi | 305 | nM | Ki | J Med Chem (2002) 45: 3703-3708 [PMID:12166943] |
ChEMBL | Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 7.28 | pKi | 53 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
ChEMBL | Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]R-PIA | B | 7.28 | pKi | 52.7 | nM | Ki | J Med Chem (1998) 41: 2835-2845 [PMID:9667972] |
ChEMBL | Displacement of [3H]DPCPX from Adenosine A1 receptor of rat brain membranes | B | 7.28 | pKi | 52.7 | nM | Ki | J Med Chem (1999) 42: 4473-4478 [PMID:10579811] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 7.6 | pKi | 25 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
ChEMBL | Displacement of [3H]-CGH 21680 from Adenosine A2A receptor of rat striatal membranes | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
ChEMBL | Displacement of specific [3H]-CGS- 21680 binding at Adenosine A2A receptor in rat striatal membranes. | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (1997) 40: 2596-2608 [PMID:9258367] |
ChEMBL | Inhibition of [3H]CGS-21680 binding to rat Adenosine A2A receptor expressed in HEK293 cells | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2002) 45: 3703-3708 [PMID:12166943] |
ChEMBL | Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680 | B | 7.99 | pKi | 10.3 | nM | Ki | J Med Chem (1998) 41: 2835-2845 [PMID:9667972] |
ChEMBL | Displacement of [3H]-SCH- 58261 from Adenosine A2A receptor in rat striatal membranes | B | 7.99 | pKi | 10.3 | nM | Ki | J Med Chem (1999) 42: 4473-4478 [PMID:10579811] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Displacement of [3H]NECA from human adenosine A3 receptor expressed in human HeLa cells incubated for 30 mins by fluorescence polarization binding assay | B | 5.77 | pKi | 1700 | nM | Ki | ACS Med Chem Lett (2022) 13: 243-249 [PMID:35178181] |
ChEMBL | Displacement of CELT-228 from human adenosine A3 receptor expressed in human HeLa cells incubated for 30 mins by fluorescence polarization binding assay | B | 5.85 | pKi | 1400 | nM | Ki | ACS Med Chem Lett (2022) 13: 243-249 [PMID:35178181] |
ChEMBL | Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay | F | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2021) 64: 8161-8178 [PMID:34120444] |
ChEMBL | Competitive binding affinity to human adenosine A3 receptor expressed in CHO cells after 90 mins by flow cytometric analysis in presence of MRS5449 | B | 8.46 | pKi | 3.46 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Displacement of [3H]HMRS7799 from human adenosine A3 receptor expressed in HEK293 cells by radioligand binding assay | B | 8.49 | pKi | 3.24 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in HEK293 cells by radioligand binding assay | B | 8.53 | pKi | 2.97 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
ChEMBL | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in human HeLa cell membrane | B | 8.61 | pKi | 2.48 | nM | Ki | Bioorg Med Chem (2010) 18: 2081-2088 [PMID:20202853] |
ChEMBL | Bnding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Binding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor in the presence of GTPgammaS using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Antagonist activity at human recombinant adenosine A3 receptor | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem (2015) 23: 9-21 [PMID:25497490] |
ChEMBL | Antagonist activity at human adenosine A3 receptor | F | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 2898-2905 [PMID:21511471] |
ChEMBL | Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligand | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (1998) 41: 2835-2845 [PMID:9667972] |
ChEMBL | Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor. | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (1997) 40: 2596-2608 [PMID:9258367] |
ChEMBL | In vitro binding affinity against human Adenosine A3 receptor | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 31-34 [PMID:10636237] |
ChEMBL | Displacement of [125]AB-MECA from human Adenosine A3 receptor expressed in HEK293 cells | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (1999) 42: 4473-4478 [PMID:10579811] |
ChEMBL | Inhibition of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (2002) 45: 3703-3708 [PMID:12166943] |
ChEMBL | Displacement of [3H]MRE 3008F20 from human adenosine A3 receptor expressed in CHO cells | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (2006) 49: 4085-4097 [PMID:16821770] |
ChEMBL | In vitro binding affinity at human Adenosine A3 receptor from HEK293 cells by [125I]AB-MECA displacement. | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells after 90 mins by gamma counting analysis | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
GtoPdb | - | - | 9.2 | pKi | 0.63 | nM | Ki |
Neuropharmacology (1997) 36: 1157-65 [PMID:9364471]; J Med Chem (1996) 39: 4142-8 [PMID:8863790]; Auton Autacoid Pharmacol (2006) 26: 191-200 [PMID:16553647]; Br J Pharmacol (2001) 132: 1017-26 [PMID:11226132] |
ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9.23 | pKi | 0.59 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
ChEMBL | Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay | F | 8.14 | pIC50 | 7.2 | nM | IC50 | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
ChEMBL | Binding affinity of adenosine derivative for endogenous rat Adenosine A3 receptor expressed on CHO cell | B | 8 | pKi | >10 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 6.5 | pKi | - | - | - | Biochem Pharmacol (2004) 68: 305-12 [PMID:15194002] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]