ChEMBL ligand: CHEMBL44884 (Etambutol, Ethambutol)
Pantothenate synthetase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6069] [UniProtKB: P9WIL5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Pantothenate synthetase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6069] [UniProtKB: P9WIL5]
ChEMBL	Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3)	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem (2014) 22: 1938-1947 [PMID:24565972]
ChEMBL	Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem (2014) 22: 4223-4232 [PMID:24953948]
ChEMBL	Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ formation by spectrophotmetry in presence of NADH	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem (2016) 24: 1298-1307 [PMID:26867485]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]