Synonyms: WP 1066 | WP-1066
Compound class:
Synthetic organic
Comment: WP1066 is a novel inhibitor of STAT3 and JAK2 [7]. It is orally bioavailable, and has demonstrated antineoplastic and immunomodulatory activities in vitro and in vivo [1-3,6]. WP1066 has also been reported as a channel blocker at the KV1.3 voltage-gated potassium channel (KCNA3) that preferentially interacts with open channels [5].
An analogue of WP1066, WP1220 (structure undisclosed, Nov. 2022), is another clinical lead STAT3 inhibitor. WP1220 is in development for topical application as a therapy for the dermatological condition mycosis fungoides, the most common type of cutaneous T-cell lymphoma (CTCL). ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide |
Synonyms ![]() |
WP 1066 | WP-1066 |
Database Links ![]() |
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CAS Registry No. | 857064-38-1 |
ChEMBL Ligand | CHEMBL1923234 |
GtoPdb PubChem SID | 249565655 |
PubChem CID | 11210478 |
Search Google for chemical match using the InChIKey | VFUAJMPDXIRPKO-LQELWAHVSA-N |
Search Google for chemicals with the same backbone | VFUAJMPDXIRPKO |
UniChem Compound Search for chemical match using the InChIKey | VFUAJMPDXIRPKO-LQELWAHVSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VFUAJMPDXIRPKO-LQELWAHVSA-N |