tetracycline [Ligand Id: 10927] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: ChEMBL1440 (Achromycin, Achromycin v, Cyclopar, E701, Economycin, Liquamycin, NSC-108579, Panmycin, Supramycin, Sustamycin, Tetrabid organon, Tetracycline, Tetracyn, Vetquamycin)
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  • Multidrug translocase mdfA in Escherichia coli [ChEMBL: CHEMBL4785] [UniProtKB: P0AEY8]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 5.22 pIC50 6060 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Multidrug translocase mdfA in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4785] [UniProtKB: P0AEY8]
ChEMBL Inhibition of [3H]tetracycline uptake into everted membrane vesicles, prepared from tetracycline resistant Escherichia coli D1-209 F 4.88 pIC50 13200 nM IC50 J Med Chem (1993) 36: 370-377 [PMID:8426364]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs F 5.66 pIC50 2190 nM IC50 Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533]
ChEMBL Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 6.16 pIC50 696.7 nM IC50 J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.4 pIC50 397.1 nM IC50 J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 6.44 pIC50 364.7 nM IC50 J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.49 pIC50 323.9 nM IC50 J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J Med Chem (2009) 52: 3784-3793 [PMID:19463000]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]