tetracycline [Ligand Id: 10927] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: ChEMBL1440 (Liquamycin, Achromycin, NSC-108579, Panmycin, Sustamycin, Vetquamycin, Achromycin v, Economycin, Tetracycline, Cyclopar, E701, Supramycin, Tetracyn, Tetrabid organon)
  • Multidrug translocase mdfA in Escherichia coli K-12 [ChEMBL: CHEMBL4785] [UniProtKB: P0AEY8]
  • This target only has 0 pki data point
  • 0
1 ChEMBL1440_lig_chart_1 Multidrug translocase mdfA Escherichia coli K-12
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
2 ChEMBL1440_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
  • This target only has 1 pki data point
  • 5
3 ChEMBL1440_lig_chart_3 Purinergic receptor P2Y12 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Multidrug translocase mdfA in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4785] [UniProtKB: P0AEY8]
ChEMBL Inhibition of [3H]tetracycline uptake into everted membrane vesicles, prepared from tetracycline resistant Escherichia coli D1-209 F 4.88 pIC50 13200 nM IC50 J. Med. Chem. (1993) 36: 370-377 [PMID:8426364]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs F 5.66 pIC50 2190 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 307-316 [PMID:17060533]
ChEMBL Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 6.16 pIC50 696.7 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.4 pIC50 397.1 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 6.44 pIC50 364.7 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.49 pIC50 323.9 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2009) 52: 3784-3793 [PMID:19463000]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]