tetracycline [Ligand Id: 10927] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: ChEMBL1440 (Achromycin, Achromycin v, Cyclopar, E701, Economycin, Liquamycin, NSC-108579, Panmycin, Supramycin, Sustamycin, Tetrabid organon, Tetracycline, Tetracyn, Vetquamycin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 5.22 | pIC50 | 6060 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Multidrug translocase mdfA in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4785] [UniProtKB: P0AEY8] | ||||||||
| ChEMBL | Inhibition of [3H]tetracycline uptake into everted membrane vesicles, prepared from tetracycline resistant Escherichia coli D1-209 | F | 4.88 | pIC50 | 13200 | nM | IC50 | J Med Chem (1993) 36: 370-377 [PMID:8426364] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs | F | 5.66 | pIC50 | 2190 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533] |
| ChEMBL | Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 6.16 | pIC50 | 696.7 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.4 | pIC50 | 397.1 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 6.44 | pIC50 | 364.7 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.49 | pIC50 | 323.9 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Displacement of [3H]PSB0413 from human platelet P2Y12 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3784-3793 [PMID:19463000] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
