Synonyms: CHIR 98014 | CHIR98014
Compound class:
Synthetic organic
Comment: CHIR-98014 is a potent ATP-competitive inhibitor of glycogen synthase kinase-3α (GSK-3α) and GSK-3β [5].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine |
Synonyms |
CHIR 98014 | CHIR98014 |
Database Links | |
Specialist databases | |
Reactome Drug | R-ALL-9687681 |
Reactome Reaction | R-HSA-9687724 |
Other databases | |
CAS Registry No. | 252935-94-7 |
ChEMBL Ligand | CHEMBL3185148 |
GtoPdb PubChem SID | 249565696 |
PubChem CID | 53396311 |
Search Google for chemical match using the InChIKey | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | MDZCSIDIPDZWKL |
UniChem Compound Search for chemical match using the InChIKey | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
CHIR 98014 (links to external site)
Cat. No. 6695 |