CHIR-98014

Ligand id: 8016

Name: CHIR-98014

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 149.19
Molecular weight 485.09
XLogP 4.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 9.2 pIC50 - 5
pIC50 9.2 (IC50 5.8x10-10 M) [5]
glycogen synthase kinase 3 alpha Hs Inhibitor Inhibition 9.2 pIC50 - 5
pIC50 9.2 (IC50 6.5x10-10 M) [5]