Ligand id: 8016

Name: CHIR-98014

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 149.19
Molecular weight 485.09
XLogP 4.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
GSK-3 negatively regulates several aspects of insulin signalling, and upregulated GSK-3 activity may be involved in the development of insulin resistance in type 2 diabetes [2,4] and in neurodegenerative disease [1,3,6]. GSK-3 inhibitors have therefore become the focus of intense drug discovery efforts.