calcifediol [Ligand Id: 6921] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1040 (Calcifediol)
  • Sterol regulatory element-binding protein 1 in Human [ChEMBL: CHEMBL4630818] [UniProtKB: P36956]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sterol regulatory element-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630818] [UniProtKB: P36956]
ChEMBL Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay B 5.93 pIC50 1176 nM IC50 J Med Chem (2021) 64: 5689-5709 [PMID:33899473]
Vitamin D receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5601] [UniProtKB: P48281]
ChEMBL Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysis B 6.22 pEC50 600 nM EC50 Eur J Med Chem (2019) 162: 495-506 [PMID:30471551]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]