calcifediol [Ligand Id: 6921] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1040 (Calcifediol)
  • Sterol regulatory element-binding protein 1 in Human [ChEMBL: CHEMBL4630818] [UniProtKB: P36956]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sterol regulatory element-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630818] [UniProtKB: P36956]
ChEMBL Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay B 5.93 pIC50 1176 nM IC50 J Med Chem (2021) 64: 5689-5709 [PMID:33899473]
Vitamin D receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5601] [UniProtKB: P48281]
ChEMBL Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysis B 6.22 pEC50 600 nM EC50 Eur J Med Chem (2019) 162: 495-506 [PMID:30471551]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]