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ChEMBL ligand: CHEMBL1040 (Calcifediol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Sterol regulatory element-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630818] [UniProtKB: P36956] | ||||||||
ChEMBL | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay | B | 5.93 | pIC50 | 1176 | nM | IC50 | J Med Chem (2021) 64: 5689-5709 [PMID:33899473] |
Vitamin D receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5601] [UniProtKB: P48281] | ||||||||
ChEMBL | Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysis | B | 6.22 | pEC50 | 600 | nM | EC50 | Eur J Med Chem (2019) 162: 495-506 [PMID:30471551] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]