L-740093 [Ligand Id: 881] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL420783 (L-740093)
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
GtoPdb - - 5.8 pKi - - - Mol Pharmacol (1994) 46: 943-8 [PMID:7969084]
ChEMBL Displacement of [125I]-BH CCK-8S from Cholecystokinin type A receptor in rat pancreas B 5.79 pIC50 1604 nM IC50 Bioorg Med Chem Lett (1995) 5: 3023-3026
ChEMBL Inhibition of ligand binding to Cholecystokinin type A receptor from rat pancreatic tissue. B 5.8 pIC50 1600 nM IC50 J Med Chem (1997) 40: 2491-2501 [PMID:9258356]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
GtoPdb - - 9.2 pIC50 0.63 nM IC50 Regul Pept (2002) 103: 29-37 [PMID:11738246]
ChEMBL Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex B 10 pIC50 0.1 nM IC50 Bioorg Med Chem Lett (1995) 5: 3023-3026
ChEMBL Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane. B 10 pIC50 0.1 nM IC50 J Med Chem (1997) 40: 2491-2501 [PMID:9258356]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]