L-740093 [Ligand Id: 881] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL420783 (L-740093) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | - | - | - | Mol Pharmacol (1994) 46: 943-8 [PMID:7969084] |
| ChEMBL | Displacement of [125I]-BH CCK-8S from Cholecystokinin type A receptor in rat pancreas | B | 5.79 | pIC50 | 1604 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 3023-3026 |
| ChEMBL | Inhibition of ligand binding to Cholecystokinin type A receptor from rat pancreatic tissue. | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (1997) 40: 2491-2501 [PMID:9258356] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| GtoPdb | - | - | 9.2 | pIC50 | 0.63 | nM | IC50 | Regul Pept (2002) 103: 29-37 [PMID:11738246] |
| ChEMBL | Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 3023-3026 |
| ChEMBL | Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane. | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1997) 40: 2491-2501 [PMID:9258356] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
