Synonyms: compound 23 [PMID: 38316747]
Compound class:
Synthetic organic
Comment: This is a PROTAC degrader that targets the Son-of-sevenless homologue 1 (SOS1) protein [1] as a mechanism to disrupt RAS activation in cancers, particularly for potential to improve the antitumour response to KRASG12C inhibitors. PROTAC 23 engages SOS1 via a target-specific warhead (BI3406) that is linked to a ligand that engages the VHL E3 ubiquitin ligase.
|
|
Classification ![]() |
|
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
compound 23 [PMID: 38316747] |
Database Links ![]() |
|
GtoPdb PubChem SID | 491299926 |
PubChem CID | 171037440 |
Search Google for chemical match using the InChIKey | PZZOZVWRQJUBBH-VXFROBSSSA-N |
Search Google for chemicals with the same backbone | PZZOZVWRQJUBBH |
UniChem Compound Search for chemical match using the InChIKey | PZZOZVWRQJUBBH-VXFROBSSSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PZZOZVWRQJUBBH-VXFROBSSSA-N |