ChEMBL ligand: CHEMBL982 (JF-1, JKB-121, Nalmefene, Nalmefene hydrochloride dihydrate, Nalmefene hydrochloride hydrate, Nalmetrene, ORF 1167, ORF-1167, ORF 11676, ORF-11676, Revex, Selincro, SRD-174, SRD174)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Activity at human delta opioid receptor by [35S]GTPgammaS binding assay	F	9.04	pKd	0.91	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cell membranes after 3 hrs by scintillation counting	B	7.8	pKi	16	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells	B	7.88	pKi	13.26	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	7.88	pKi	13.26	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	8.03	pKi	9.3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	8.1	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenates	B	8.47	pKi	3.4	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells	B	8.99	pKi	1.03	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	8.99	pKi	1.03	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
ChEMBL	Displacement of [3H]U69,593 from human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	10.08	pKi	0.08	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue	B	8.7	pKi	2	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Activity at human mu opioid receptor by [35S]GTPgammaS binding assay	F	9.53	pKd	0.3	nM	Kd	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells	B	9.04	pKi	0.91	nM	Ki	J Med Chem (2008) 51: 1913-1924 [PMID:18298057]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometry	B	9.04	pKi	0.91	nM	Ki	Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	9.36	pKi	0.44	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	9.5	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting	B	9.62	pKi	0.24	nM	Ki	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates	B	9.54	pKi	0.29	nM	Ki	J Med Chem (1993) 36: 2842-2850 [PMID:8410999]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]