octyl thiophosphatidic acid [Ligand Id: 6995] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL427017
  • LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
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  • LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
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  • LPA5 receptor in Rat [GtoPdb: 124]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
ChEMBL Activity at LPA1 receptor transfected RH7777 cells B 6.86 pKi 139 nM Ki Bioorg Med Chem Lett (2006) 16: 633-640 [PMID:16263282]
ChEMBL Activity at LPA1 receptor transfected RH7777 cells B 6.48 pIC50 328 nM IC50 Bioorg Med Chem Lett (2006) 16: 633-640 [PMID:16263282]
LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
ChEMBL Activity at LPA3 receptor transfected RH7777 cells B 7.17 pKi 67 nM Ki Bioorg Med Chem Lett (2006) 16: 633-640 [PMID:16263282]
ChEMBL Activity at LPA3 receptor transfected RH7777 cells B 6.74 pIC50 184 nM IC50 Bioorg Med Chem Lett (2006) 16: 633-640 [PMID:16263282]
LPA5 receptor in Rat [GtoPdb: 124]
GtoPdb - - 5.68 pEC50 2100 nM EC50 J Biol Chem (2009) 284: 17304-19 [PMID:19366702]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]