PBF-509 [Ligand Id: 10193] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3638684 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | Antagonism of rolipram-induced cAMP accummulation in CHO cells expressing the human A2A receptor, as measured using a proprietary enzymeimmunoassay. | - | 7.6 | pKi | 25 | nM | Ki |
Neoplasia (2017) 19: 530-536 [PMID:28582704]; WO2011121418A1. 4-aminopyrimidine derivatives and their as as adenosine A2A receptor antagonists (2011) |
| GtoPdb | Determined in a competitive radioligand binding assay using membranes prepared from HeLa cells expressing human A2A receptor. | - | 7.92 | pKi | 12 | nM | Ki |
Neoplasia (2017) 19: 530-536 [PMID:28582704]; WO2011121418A1. 4-aminopyrimidine derivatives and their as as adenosine A2A receptor antagonists (2011) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
