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ChEMBL ligand: CHEMBL29097 (MK-886) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292] | ||||||||
ChEMBL | Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA | B | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 11 hrs by ELISA | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Inhibition of FLAP in human leukocytes assessed as decrease in ionophore A23187-induced LT biosynthesis after 10 mins | B | 6.99 | pIC50 | 102 | nM | IC50 | Medchemcomm (2018) 9: 212-225 [PMID:30108915] |
ChEMBL | Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 3 hr by ELISA in presence of 0.5% human serum albumin | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Binding affinity to FLAP | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2009) 52: 4968-4972 [PMID:19719242] |
ChEMBL | Inhibition of FLAP | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1604-1609 [PMID:20144869] |
ChEMBL | Inhibition of FLAP | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2008) 51: 4059-4067 [PMID:18459759] |
ChEMBL | Inhibition of FLAP (unknown origin) | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 907-911 [PMID:23266122] |
ChEMBL | Binding affinity of compound for 5-lipoxygenase activating protein protein by FLAP binding assay | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
ChEMBL | The compound was tested for the inhibition of binding of [125I]- L- 691,831 binding to 5-lipoxygenase activating protein (FLAP) | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 1395-1398 |
ChEMBL | Inhibition of 5-lipoxygenase activating protein using human leukocyte membrane preparations | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1995) 38: 4538-4547 [PMID:7473582] |
ChEMBL | Displacement of [125I]-L-691831 from FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assay | B | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2018) 153: 34-48 [PMID:28784429] |
ChEMBL | Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA in presence of 0.5% human serum albumin | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg Med Chem (2012) 20: 3728-3741 [PMID:22607880] |
ChEMBL | Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 1 hr by ELISA in absence of human serum albumin | B | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
ChEMBL | Antagonist activity at FLAP in human PMNC assessed as inhibition of A23187-induced LTB4 biosynthesis pre-incubated for 2 mins followed by addition of A23187 measured after 5 mins by radioimmunoassay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2016) 59: 5970-5986 [PMID:26791385] |
ChEMBL | Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 5 mins by ELISA in absence of human serum albumin | B | 8.66 | pIC50 | 2.2 | nM | IC50 | J Med Chem (2011) 54: 8013-8029 [PMID:22059882] |
5-LOX/5-lipoxygenase/FLAP in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111402] [GtoPdb: 1385] [UniProtKB: P09917, P20292] | ||||||||
ChEMBL | Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay | F | 6.47 | pIC50 | 340 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1547-1552 |
ChEMBL | Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1547-1552 |
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
ChEMBL | Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and arachidonic acid addition and measured after 10 mins by RP-HPLC analysis | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2018) 150: 876-899 [PMID:29597170] |
ChEMBL | Inhibition of 5-LO in PMNL cells | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2008) 51: 8068-8076 [PMID:19053751] |
ChEMBL | Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2011) 19: 3394-3401 [PMID:21570310] |
ChEMBL | Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2011) 54: 4490-4507 [PMID:21591611] |
ChEMBL | Inhibition of 5-lipoxygenase in A23187-stimulated human polymorphonuclear leukocytes using arachidonic acid as substrate incubated 15 mins prior to substrate addition measured after 10 mins by HPLC analysis | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2013) 56: 9031-9044 [PMID:24171493] |
ChEMBL | The compound was tested for inhibitory activity against LT synthesis in human polymorphonuclear leukocytes[PMNS] | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (1992) 35: 2501-2524 [PMID:1635053] |
ChEMBL | Inhibition of Human 5-lipoxygenase | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (1995) 38: 4538-4547 [PMID:7473582] |
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
ChEMBL | The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in rat RBL-2H3 cells | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1992) 35: 2501-2524 [PMID:1635053] |
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 5 mins by HPLC analysis | B | 5.1 | pIC50 | 8000 | nM | IC50 | Eur J Med Chem (2018) 153: 2-28 [PMID:29329790] |
ChEMBL | Inhibition of ovine COX-1 assessed as 12-HHT formation preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 5 mins by HPLC analysis | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (2016) 59: 5970-5986 [PMID:26791385] |
ChEMBL | Inhibition of ovine COX1 | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2008) 51: 8068-8076 [PMID:19053751] |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | Inhibition of human recombinant COX2 in cell-free system by enzyme immunoassay | B | 4.24 | pIC50 | 58000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 5418-5422 [PMID:25453800] |
ChEMBL | Inhibition of human recombinant COX2 | B | 8 | pIC50 | >10 | nM | IC50 | J Med Chem (2008) 51: 8068-8076 [PMID:19053751] |
Leukotriene C4 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743183] [GtoPdb: 1391] [UniProtKB: Q16873] | ||||||||
ChEMBL | Inhibition of recombinant LTC4S (unknown origin) expressed in COS cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2022) 231: 114167-114167 [PMID:35152061] |
Macrophage-expressed gene 1 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3414409] [UniProtKB: Q2M385] | ||||||||
ChEMBL | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using PGH2 substrate by RP-HPLC method | B | 5.66 | pIC50 | 2200 | nM | IC50 | Eur J Med Chem (2015) 94: 132-139 [PMID:25765759] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
ChEMBL | Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells by cell-free assay | B | 5.41 | pIC50 | 3900 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127992-127992 [PMID:33775835] |
ChEMBL | Inhibition of mPGES1 (unknown origin) using PGH2 as substrate incubated for 30 mins prior to substrate addition by PGH2-coupled spectrophotometric analysis | B | 5.41 | pIC50 | 3900 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 75-80 [PMID:23218602] |
ChEMBL | Inhibition of microsomal PGES1 using PGH2 as substrate by RP-HPLC method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7335-7339 [PMID:23147075] |
ChEMBL | Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2 | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1329-1333 [PMID:21310608] |
ChEMBL | Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cells microsomal membranes assessed as reduction in conversion of PGH2 to PGE2 pre-incubated for 15 mins followed by PGH2 substrate addition measured after 1 min by RP-HPLC method | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Nat Prod (2017) 80: 731-734 [PMID:28165233] |
ChEMBL | Inhibition of human recombinant microsomal PGES-1 expressed in freestyle 293-f cells assessed as conversion of PGH2 to PGE2 after 15 mins by enzyme immunoassay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2011) 19: 6077-6086 [PMID:21920764] |
ChEMBL | Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins followed by PGH2 addition measured after 1 min by RP-HPLC analysis | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Nat Prod (2017) 80: 699-706 [PMID:28240894] |
ChEMBL | Inhibition of mPGES1 | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2008) 51: 8068-8076 [PMID:19053751] |
ChEMBL | Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using PGH2 substrate by RP-HPLC method | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2015) 23: 4839-4845 [PMID:26088337] |
ChEMBL | Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Nat Prod (2014) 77: 1445-1451 [PMID:24844534] |
ChEMBL | Inhibition of mPGES-1 from human A549 cell microsomal membranes using PGH2 as substrate incubated 15 mins prior to substrate addition measured after 1 min by RP-HPLC analysis | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2013) 56: 9031-9044 [PMID:24171493] |
ChEMBL | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2011) 54: 4490-4507 [PMID:21591611] |
ChEMBL | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2011) 19: 3394-3401 [PMID:21570310] |
ChEMBL | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2012) 55: 8958-8962 [PMID:22992107] |
ChEMBL | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level using RP-HPLC method | B | 5.68 | pIC50 | 2110 | nM | IC50 | J Med Chem (2009) 52: 4968-4972 [PMID:19719242] |
ChEMBL | Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2008) 51: 8068-8076 [PMID:19053751] |
ChEMBL | Inhibition of PGES-1 in IL-1beta stimulated human A549 cell microsomes using PGH2 as substrate assessed as suppression of PGE2 formation preincubated for 15 mins followed by substrate addition by reversed phase-HPLC analysis | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem (2016) 24: 820-826 [PMID:26777299] |
ChEMBL | Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins followed by PGH2 addition and measured after 1 mins by EIA | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127992-127992 [PMID:33775835] |
ChEMBL | Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as inhibition of PGE2 formation incubated for 15 mins before addition of PGH2 by RP-HPLC method | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Nat Prod (2011) 74: 1779-1786 [PMID:21800856] |
ChEMBL | Inhibition of mPGES1 in human A549 cell microsomes | B | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2018) 153: 2-28 [PMID:29329790] |
ChEMBL | Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measured after 1 min by RP-HPLC method | B | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2018) 153: 2-28 [PMID:29329790] |
ChEMBL | Inhibition of mPGES1 in IL1-beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2 | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem (2009) 17: 7924-7932 [PMID:19884011] |
ChEMBL | Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production incubated for 15 mins post interleukin-1beta challenge for 72 hrs by RP-HPLC analysis | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 94-99 [PMID:26602278] |
ChEMBL | Inhibition of microsomal PGES1 (unknown origin) | B | 5.8 | pIC50 | 1600 | nM | IC50 | Medchemcomm (2015) 6: 2081-2123 |
ChEMBL | Inhibition of human mPGES1 | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1604-1609 [PMID:20144869] |
ChEMBL | Inhibition of mPGES-1 | B | 5.8 | pIC50 | 1600 | nM | IC50 | Eur J Med Chem (2012) 48: 153-163 [PMID:22209272] |
ChEMBL | Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated 20 mins prior to substrate addition measured after 30 secs by EIA | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 907-911 [PMID:23266122] |
ChEMBL | Inhibition of microsomal PGES | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem (2011) 19: 6077-6086 [PMID:21920764] |
ChEMBL | Inhibition of human recombinant mPGES-1 in assessed as conversion of PGH2 into PGE2 at 20 degC after 5 mins by HPLC-UV analysis | B | 5.89 | pIC50 | 1300 | nM | IC50 | Eur J Med Chem (2012) 48: 153-163 [PMID:22209272] |
ChEMBL | Inhibition of microsomal PGES1 in human whole blood | B | 5.96 | pIC50 | 1100 | nM | IC50 | Medchemcomm (2015) 6: 2081-2123 |
ChEMBL | Inhibition of microsomal PGES-1 (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 3296-3309 [PMID:23527738] |
mPGES2/Prostaglandin E synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7] | ||||||||
ChEMBL | Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724] |
Peroxisome proliferator-activated receptor-α in Mouse [GtoPdb: 593] [UniProtKB: P23204] | ||||||||
GtoPdb | - | - | 6 | pIC50 | - | - | - | Biochem J (2001) 353: 253-8 [PMID:11139388] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]