ChEMBL ligand: CHEMBL13647 (BMY-7378)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130] α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1A adrenergic receptor	B	6.42	pKd	380.19	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Binding affinity at human cloned Alpha-1A adrenergic receptor in chinese hamster ovary cells by [3H]-prazosin displacement.	B	6.36	pKi	436.52	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1a adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	6.41	pKi	389.05	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1A adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	6.42	pKi	380.19	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cells	B	6.42	pKi	380.19	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement [3H]prazosin of human recombinant alpha1A adrenergic receptor expressed in CHO cells by rapid filtration technique	B	6.42	pKi	380.19	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor	B	6.42	pKi	380.19	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Displacement of [3H]prazosin from human cloned alpha1A adrenoceptor expressed in CHO cells	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1A adrenergic receptor (n >= 2)	B	6.53	pKi	294	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Binding affinity for human Alpha-1A adrenergic receptor	B	6.54	pKi	290	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	In vitro binding affinity at human Alpha-1A adrenergic receptor.	B	6.6	pKi	251	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactive	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 657-664 [PMID:15664832]
ChEMBL	Binding affinity for human Alpha-1A adrenergic receptor	B	6.89	pKi	130	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb	-	-	7	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL	Binding affinity towards bovine Alpha-1A adrenergic receptor	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens	B	5.98	pKd	1047.13	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	F	6.94	pKd	114.82	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	F	7.01	pKd	97.72	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1A adrenergic receptor	B	6.21	pKi	620	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]prazosin in epididymal rat vas deferens.	B	6.31	pKi	494.7	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity towards rat Alpha-1A adrenergic receptor	B	6.95	pKi	112	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb	-	-	7	pKi	-	-	-	Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1B adrenoceptor expressed in CHO cells	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Displacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration technique	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1b adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1B adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells	B	6.15	pKi	707.95	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	In vitro binding affinity at human Alpha-1B adrenergic receptor.	B	6.2	pKi	631	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding affinity for human Alpha-1B adrenergic receptor	B	6.72	pKi	191	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adrenergic receptor (n >= 2)	B	6.72	pKi	191	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen	B	6.77	pKi	168.2	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity towards human Alpha-1B adrenergic receptor	B	7.03	pKi	94.3	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor	B	7.16	pKi	69.18	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.	B	7.19	pKi	64.57	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
GtoPdb	-	-	7.5	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen	F	7.37	pKd	42.66	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor	F	7.48	pKd	33.11	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.	F	7.55	pKd	28.18	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1B adrenergic receptor	B	6.48	pKi	328	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	In vitro binding affinity at human Alpha-1D adrenergic receptor.	B	8.2	pKi	6.3	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding affinity for human Alpha-1D adrenergic receptor	B	8.8	pKi	1.6	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)	B	8.8	pKi	1.6	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor	B	8.84	pKi	1.45	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells	B	8.89	pKi	1.29	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.	B	8.89	pKi	1.29	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
GtoPdb	-	-	9.1	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
ChEMBL	Binding affinity towards human Alpha-1D adrenergic receptor	B	9.11	pKi	0.78	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL	In vitro functional activity at Alpha-1D adrenergic receptor in rat aorta	B	8.22	pKd	6.03	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.	F	8.34	pKd	4.57	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor	F	8.4	pKd	3.98	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr	F	8.52	pKd	3.02	nM	Kd	Eur J Med Chem (2011) 46: 3000-3012 [PMID:21549456]
ChEMBL	Binding affinity to the adrenergic receptor alpha-1D of rat aorta	B	8.07	pKi	8.6	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor	B	8.62	pKi	2.4	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
GtoPdb	-	-	9	pKi	-	-	-	Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
ChEMBL	Binding affinity towards rat Alpha-1D adrenergic receptor	B	9.02	pKi	0.96	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity for human Dopamine receptor D2	B	7.85	pKi	14	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Displacement of [3H]spiperone from rat brain Dopamine receptor D2	B	7.31	pKi	48.98	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity at native Dopamine receptor D2 in rat striatum by [3H]spiperone displacement.	B	7.32	pKi	47.86	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	In vitro binding affinity towards Dopamine receptor D2 in rat striatum was determined using [3H]-spiperone as radioligand	B	7.76	pKi	17.38	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL	Binding affinity for rat Dopamine receptor D3	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity at human cloned 5-hydroxytryptamine 1A receptor expressed in HeLa cells by [3H]8-hydroxy-2-(di-n-propylamino)tetraline displacement.	B	8.76	pKi	1.74	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in human HeLa cells	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HeLa cell membranes after 30 mins by TopCount liquid scintillation counting method	B	8.9	pKi	1.26	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting	B	8.9	pKi	1.26	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Inhibitory constant value against the 5-hydroxytryptamine 1A receptor	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1185-1188 [PMID:15686938]
ChEMBL	Displacement [3H]8-OH-DPAT of human cloned 5HT1A receptor expressed in human HeLa cells by rapid filtration technique	B	8.9	pKi	1.26	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor	B	9.03	pKi	0.93	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]8-OH-DPAT) as radioligand	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 1A receptor	B	9.34	pKi	0.46	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in human HeLa cells	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in human HeLa cell membranes after 30 mins by liquid scintillation counting method	B	9.43	pKi	0.37	nM	Ki	Eur J Med Chem (2017) 125: 233-244 [PMID:27662034]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in human HeLa cells incubated for 30 mins by radioligand competition binding assay	B	9.43	pKi	0.37	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 mins	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant 5-hydroxytryptamine receptor 1A	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
GtoPdb	-	-	8	pIC50	-	-	-	Life Sci (1997) 60: 653-65 [PMID:9048968]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	7.1	pKi	79.43	nM	Ki	J Med Chem (1996) 39: 126-134 [PMID:8568799]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT	B	8.09	pKi	8.2	nM	Ki	J Med Chem (1996) 39: 1125-1129 [PMID:8676348]
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	8.62	pKi	2.4	nM	Ki	J Med Chem (1996) 39: 126-134 [PMID:8568799]
ChEMBL	Binding affinity at 5-hydroxytryptamine 1A receptor	B	8.71	pKi	1.95	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]
ChEMBL	Compound was evaluated for its ability to displace [3H]8-OH-DPAT from serotonin 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes	B	8.62	pIC50	2.4	nM	IC50	Bioorg Med Chem Lett (1996) 6: 689-694
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL	Binding affinity at 5-hydroxytryptamine 1B receptor	B	5	pKi	>10000	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]