taladegib [Ligand Id: 10333] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2142592 (Taladegib, LY-2940680)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SMO in Human [GtoPdb: 239] [UniProtKB: Q99835]
GtoPdb Gli-luc reporter assay. - 8.2 pIC50 6.3 nM IC50 Eur J Med Chem (2017) 138: 384-395 [PMID:28688278]
SMO/Smoothened homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6080] [GtoPdb: 239] [UniProtKB: P56726]
ChEMBL Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated for 1 to 2 hrs followed by SAG addition and measured after 24 hrs by Bright-Glo luciferase reporter gene assay F 8.62 pIC50 2.4 nM IC50 MedChemComm (2017) 8: 1332-1336

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]