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ChEMBL ligand: CHEMBL403893 (Thebaine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells | B | 5.13 | pKi | 7400 | nM | Ki | J Biol Chem (2007) 282: 27126-27132 [PMID:17616524] |
GtoPdb | Measuring ligand-indiced activation of Gi signalling in a FRET-based assay | - | 5.25 | pEC50 | 5600 | nM | EC50 | J Biol Chem (2007) 282: 27126-27132 [PMID:17616524] |
ChEMBL | Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer | B | 5.25 | pEC50 | 5600 | nM | EC50 | J Biol Chem (2007) 282: 27126-27132 [PMID:17616524] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]