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ChEMBL ligand: CHEMBL4210086 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
GtoPdb | - | - | 9.07 | pIC50 | 0.85 | nM | IC50 | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
ChEMBL | Inhibition of FAAH1 in Wistar rat brain homogenates using [3H]anandamide as substrate incubated for 30 mins by liquid scintillation counting method | B | 9.07 | pIC50 | 0.85 | nM | IC50 | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
GtoPdb | - | - | 9.11 | pKi | 0.78 | nM | Ki | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
ChEMBL | Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis | B | 9.11 | pKi | 0.78 | nM | Ki | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
GtoPdb | - | - | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
ChEMBL | Displacement of [125I]iodomelatonin from human MT2 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (2018) 61: 7902-7916 [PMID:30126274] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]