ChEMBL ligand: CHEMBL270190 (ADL 8-2698, ADL-8-2698, Alvimopan, Alvimopan anhydrous, Alvimopan dihydrate, Anhydrous alvimopan, Entereg, LY246736, LY-246736, LY-246736 DIHYDRATE)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] There should be some charts here, you may need to enable JavaScript!
Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	-	-	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-12 [PMID:18313920]
ChEMBL	Displacement of [3H]diprenorphine from human cloned delta opioid receptor	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920]
ChEMBL	Displacement of [3H]DPN from recombinant human delta opioid receptor expressed in CHOK1 cell membranes	B	8.3	pKi	5.01	nM	Ki	Bioorg Med Chem Lett (2017) 27: 2926-2930 [PMID:28499731]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	-	-	7	pKi	100	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-12 [PMID:18313920]
ChEMBL	Displacement of [3H]diprenorphine from human cloned kappa opioid receptor	B	7	pKi	100	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Displacement of [3H]DPN from guinea pig kappa opioid receptor expressed in CHOK1 cell membranes	B	8.3	pKi	5.01	nM	Ki	Bioorg Med Chem Lett (2017) 27: 2926-2930 [PMID:28499731]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human cloned mu opioid receptor	B	9.33	pKi	0.47	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920]
GtoPdb	-	-	9.33	pKi	0.47	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2006-12 [PMID:18313920]
ChEMBL	Displacement of [3H]DPN from recombinant human mu opioid receptor expressed in CHOK1 cell membranes	B	9.5	pKi	0.32	nM	Ki	Bioorg Med Chem Lett (2017) 27: 2926-2930 [PMID:28499731]
ChEMBL	Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay	F	8.5	pIC50	3.16	nM	IC50	J Med Chem (2017) 60: 6733-6750 [PMID:28726402]
ChEMBL	Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2017) 60: 6733-6750 [PMID:28726402]
ChEMBL	Antagonist activity at human cloned mu opioid receptor assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S binding	F	8.77	pIC50	1.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2006-2012 [PMID:18313920]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL	Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automated patch clamp platform	F	5.3	pIC50	5011.87	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787]
ChEMBL	Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using IonWorks Quattro automated patch clamp platform	F	4.3	pIC50	50118.72	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]