telcagepant [Ligand Id: 703] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL236593 (Mk-0974, Telcagepant, MK-0974, MK0974)
  • Calcitonin gene-related peptide 1 in Human [ChEMBL: CHEMBL5293] [UniProtKB: P06881]
  • Calcitonin gene-related peptide 1 in Rat [ChEMBL: CHEMBL5735] [UniProtKB: P01256]
There should be some charts here, you may need to enable JavaScript!
  • calcitonin receptor-like receptor/Calcitonin gene-related peptide type 1 receptor in Human [ChEMBL: CHEMBL3798] [GtoPdb: 47] [UniProtKB: Q16602]
There should be some charts here, you may need to enable JavaScript!
  • CGRP receptor in Human [GtoPdb: 48]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Calcitonin gene-related peptide 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5293] [UniProtKB: P06881]
ChEMBL Inhibition of human CGRP receptor expressed in huamn HEK293 cells coexpressing CLR/RAMP1 assessed as inhibition of CGRP-stimulated cAMP production after 1 hr B 4 pKi >100000 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 6705-6708 [PMID:21982500]
ChEMBL Displacement of [125I]adrenomedullin form CGRP receptor in human SK-N-MC cell membrane by competitive binding assay B 9.11 pKi 0.78 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 6705-6708 [PMID:21982500]
ChEMBL Inhibition of human CGRP receptor expressed in huamn HEK293 cells coexpressing CLR/RAMP1 assessed as inhibition of CGRP-stimulated cAMP production after 1 hr B 8.66 pIC50 2.2 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6705-6708 [PMID:21982500]
Calcitonin gene-related peptide 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5735] [UniProtKB: P01256]
ChEMBL Inhibition of rat CGRP B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 6705-6708 [PMID:21982500]
calcitonin receptor-like receptor/Calcitonin gene-related peptide type 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3798] [GtoPdb: 47] [UniProtKB: Q16602]
ChEMBL Antagonist activity against CGRP receptor assessed as inhibition of CGRP-mediated vasorelaxation in human coronary arteries B 8.43 pKd 3.71 nM Kd J. Med. Chem. (2014) 57: 7838-7858 [PMID:24960305]
ChEMBL Reversible saturable binding affinity to human CGRP receptor using [3H]-labeled compound B 8.72 pKd 1.9 nM Kd J. Med. Chem. (2014) 57: 7838-7858 [PMID:24960305]
ChEMBL Displacement of [125I]-CGRP from human recombinant CGRP receptor B 9.1 pKi 0.8 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 2683-2686 [PMID:21251825]
ChEMBL Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1 B 9.1 pKi 0.8 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 4740-4742 [PMID:19577468]
ChEMBL Displacement of [125I]human CGRP from human CLR expressed in HEK 293 cells coexpressing human RAMP1 after 3 hrs by scintillation counting B 9.1 pKi 0.8 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6368-6372 [PMID:19818613]
ChEMBL Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cells B 9.11 pKi 0.77 nM Ki J. Med. Chem. (2007) 50: 5564-5567 [PMID:17929795]
ChEMBL Antagonist activity at human CGRP receptor B 9.11 pKi 0.77 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 3157-3161 [PMID:23632269]
ChEMBL Displacement of [125I]-hCGRP from human CGRP receptor expressed in HEK293 cells B 9.11 pKi 0.77 nM Ki ACS Med. Chem. Lett. (2013) 4: 863-868 [PMID:24900761]
ChEMBL Binding affinity to human CGRP receptor B 9.11 pKi 0.77 nM Ki J. Med. Chem. (2014) 57: 7838-7858 [PMID:24960305]
ChEMBL Antagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assay B 7.96 pIC50 11 nM IC50 J. Med. Chem. (2014) 57: 7838-7858 [PMID:24960305]
ChEMBL Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum F 7.96 pIC50 11 nM IC50 J. Med. Chem. (2007) 50: 5564-5567 [PMID:17929795]
ChEMBL Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum F 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4740-4742 [PMID:19577468]
ChEMBL Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay F 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6368-6372 [PMID:19818613]
ChEMBL Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum F 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2683-2686 [PMID:21251825]
ChEMBL Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay F 8.62 pIC50 2.4 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4740-4742 [PMID:19577468]
ChEMBL Antagonist activity against human CGRP receptor by cell based cAMP accumulation assay B 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2014) 57: 7838-7858 [PMID:24960305]
ChEMBL Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production F 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2007) 50: 5564-5567 [PMID:17929795]
ChEMBL Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay F 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2683-2686 [PMID:21251825]
ChEMBL Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay F 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6368-6372 [PMID:19818613]
CGRP receptor in Human [GtoPdb: 48]
GtoPdb - - 9.1 pKi - - - J Pharmacol Exp Ther (2008) 324: 416-21 [PMID:18039958]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]