imatinib   Click here for help

GtoPdb Ligand ID: 5687

Synonyms: CGP 57148 | Gleevec® | Glivec® | STI571
Approved drug PDB Ligand Immunopharmacology Ligand
imatinib is an approved drug (FDA & EMA (2001))
Compound class: Synthetic organic
Comment: Imatinib is a Type-2 kinase inhibitor. Its main inhibitory activity is against ABL kinase, but it has significant action at secondary targets including platelet-derived growth factor receptor (PDGFR) and stem cell growth factor receptor (KIT).

Coronavirus: imatinib is reported to block Spike protein-induced SARS-CoV and MERS-CoV fusion in vitro [8], potentially by blocking Abl2 at the endosomal membrane and disrupting the actin dynamics that are required for virus-host fusion [2]. It will be informative to determine if this holds true for SARS-CoV-2, and whether re-purposing of imatinib and/or newer Abl kinase inhibitors (dasatinib, bosutinib, ponatinib, nilotinib) could be a viable strategy against COVID-19. This approach would likely to be most effective during the early stage of infection.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 86.28
Molecular weight 493.26
XLogP 3.04
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C
Isomeric SMILES CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C
InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA & EMA (2001))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
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IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8031 imatinib
Synonyms Click here for help
CGP 57148 | Gleevec® | Glivec® | STI571
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9659761
Reactome Reaction Reactome logo R-HSA-9669854, R-HSA-9674430, R-HSA-9674095, R-HSA-9669900, R-HSA-9669859, R-HSA-9674397
Other databases
CAS Registry No. 152459-95-5
DrugBank Ligand DB00619
DrugCentral Ligand 1423
GtoPdb PubChem SID 178102314
PubChem CID 5291
Search Google for chemical match using the InChIKey KTUFNOKKBVMGRW-UHFFFAOYSA-N
Search Google for chemicals with the same backbone KTUFNOKKBVMGRW
Search PubMed clinical trials imatinib
Search PubMed titles imatinib
Search PubMed titles/abstracts imatinib
SynPHARM 78741 (in complex with ABL proto-oncogene 1, non-receptor tyrosine kinase)
UniChem Compound Search for chemical match using the InChIKey KTUFNOKKBVMGRW-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey KTUFNOKKBVMGRW-UHFFFAOYSA-N
Wikipedia Imatinib