Ligand id: 5687

Name: imatinib

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 86.28
Molecular weight 493.26
XLogP 3.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
The KIT inhibiting action of imatinib inhibits SCF-mediated effects of cord blood mast cells (CBMC) such as survival, chemotaxis, and adhesion [7]. Attenuating KIT activation using imatinib shows efficacy in either chronic allergen-induced airway inflammation and remodeling [6] or hypereosinophilic disorders [8].
Immunopharmacology Disease
Disease X-Refs Comment References
Chronic myelogenous leukemia Disease Ontology: DOID:8552
OMIM: 608232
Approved drug for CML.