ChEMBL ligand: CHEMBL312040 (Acscn-9624, Arc 1g2, BA-20684, Ciba 20-684ba, Etobedolum, Etonitazene, Etonitazine, IDS-NE-006, NIH 7607, NIH-7607)
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!
Mu-type opioid receptor in Rhesus macaque [ChEMBL: CHEMBL5799] [UniProtKB: Q9MYW9] There should be some charts here, you may need to enable JavaScript!
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	-	-	6.7	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay	B	6	pKi	>1000	nM	Ki	J Med Chem (1990) 33: 2456-2464 [PMID:2167979]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]-Diprenorphine from human mu opioid receptor expressed in HEK293-TSA cell membranes after 4 hrs by scintillation counting method	B	9.7	pKi	0.2	nM	Ki	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
GtoPdb	-	-	9.7	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
GtoPdb	Potency determined as inhibition of cAMP accumulation in a Gi-cAMP assay	-	10.52	pEC50	0.03	nM	EC50	Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
GtoPdb	Binding affinity determined in radioligand displacement assay using rat brain and [3H]DAMGO as tracer	-	8.18	pKi	6.6	nM	Ki	Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878]
ChEMBL	Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1	B	9.3	pKi	0.5	nM	Ki	J Med Chem (1990) 33: 2456-2464 [PMID:2167979]
Mu-type opioid receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5799] [UniProtKB: Q9MYW9]
ChEMBL	Binding affinity to mu opioid receptor in rhesus monkey brain membrane in absence of Na+ ions	B	10.7	pKi	0.02	nM	Ki	Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056]
ChEMBL	Binding affinity to mu opioid receptor in rhesus monkey brain membrane in presence of Na+ ions	B	11	pKi	0.01	nM	Ki	Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	-	-	6.9	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]