purmorphamine [Ligand Id: 10356] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1221984 (Purmorphamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835] | ||||||||
| ChEMBL | Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopy | B | 5.82 | pIC50 | 1500 | nM | IC50 | Nat Chem Biol (2006) 2: 29-30 [PMID:16408088] |
| GtoPdb | - | - | 6 | pEC50 | ~1000 | nM | EC50 | Nat Chem Biol (2006) 2: 29-30 [PMID:16408088] |
| SMO/Smoothened homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6080] [GtoPdb: 239] [UniProtKB: P56726] | ||||||||
| ChEMBL | Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay | B | 6.1 | pEC50 | 800 | nM | EC50 | Eur J Med Chem (2016) 121: 747-757 [PMID:27429255] |
| Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226] | ||||||||
| ChEMBL | Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assay | F | 6 | pEC50 | 1000 | nM | EC50 | Nat Chem Biol (2006) 2: 29-30 [PMID:16408088] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
