MK-2206 [Ligand Id: 7945] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1079175 (Mk-2206, MK2206, MK-2206)
  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
There should be some charts here, you may need to enable JavaScript!
  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
There should be some charts here, you may need to enable JavaScript!
  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP B 8 pIC50 10 nM IC50 ACS Med. Chem. Lett. (2014) 5: 462-467 [PMID:24900862]
ChEMBL Inhibition of Akt1 B 8.1 pIC50 8 nM IC50 J. Med. Chem. (2010) 53: 1413-1437 [PMID:20166671]
GtoPdb - - 8.3 pIC50 5 nM IC50 AACR Annual Meeting 2009 (2009) : Abstract Number: DDT01-1;
Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor.. AACR Meeting Abstracts Online; http://aacrmeetingabstracts.org
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
GtoPdb - - 7.92 pIC50 12 nM IC50 AACR Annual Meeting 2009 (2009) : Abstract Number: DDT01-1;
Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor.. AACR Meeting Abstracts Online; http://aacrmeetingabstracts.org
ChEMBL Inhibition of Akt2 B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2010) 53: 1413-1437 [PMID:20166671]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Inhibition of Akt3 B 7.19 pIC50 65 nM IC50 J. Med. Chem. (2010) 53: 1413-1437 [PMID:20166671]
GtoPdb - - 7.19 pIC50 65 nM IC50 AACR Annual Meeting 2009 (2009) : Abstract Number: DDT01-1;
Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor.. AACR Meeting Abstracts Online; http://aacrmeetingabstracts.org

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]