PF0998425 [Ligand Id: 6698] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL458084 (PF-0998425) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay | F | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2008) 51: 7010-7014 [PMID:18921992] |
| ChEMBL | Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2008) 51: 7010-7014 [PMID:18921992] |
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Med Chem (2008) 51: 7010-4 [PMID:18921992] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Inhibition of progesterone receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 7010-7014 [PMID:18921992] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
