lomitapide [Ligand Id: 7439] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL354541 (AEGR-733, BMS-201038, BMS-201038-01, Lojuxta, Lomitapide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Microsomal triglyceride transfer protein large subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2569] [UniProtKB: P55157] | ||||||||
| ChEMBL | In vitro inhibition of human microsomal triglyceride transfer protein using triglyceride transfer assay | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2001) 44: 851-856 [PMID:11300866] |
| ChEMBL | In vitro inhibitory concentration against human Microsomal triglyceride transfer protein | F | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5067-5070 [PMID:15380200] |
| ChEMBL | In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay | F | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2001) 44: 851-856 [PMID:11300866] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
