prazosin [Ligand Id: 503] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2
  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
  • α1A-adrenoceptor in Rat [GtoPdb: 22] [UniProtKB: P43140]
  • 9.5
1 CHEMBL2_lig_chart_1 α1A-adrenoceptor HumanRat
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  • α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
  • This target only has 1 pki data point
  • 9.9
2 CHEMBL2_lig_chart_2 α1B-adrenoceptor Human
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  • α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
  • This target only has 1 pki data point
  • 10.2
3 CHEMBL2_lig_chart_3 α1D-adrenoceptor Human
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  • α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 6.5
4 CHEMBL2_lig_chart_4 α2A-adrenoceptor Human
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 7.5
5 CHEMBL2_lig_chart_5 α2B-adrenoceptor Human
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 8
6 CHEMBL2_lig_chart_6 α2C-adrenoceptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 9.9 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
FEBS Lett (1998) 422: 279-83 [PMID:9490024];
Br J Pharmacol (1999) 127: 252-8 [PMID:10369480];
Eur J Pharmacol (1999) 370: 337-43 [PMID:10334511]
α1A-adrenoceptor in Rat [GtoPdb: 22] [UniProtKB: P43140]
GtoPdb - - 9.5 pKi - - - J Biol Chem (2001) 276: 25366-71 [PMID:11331292]
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb - - 9.9 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Br J Pharmacol (1999) 127: 252-8 [PMID:10369480]
α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb - - 10.2 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Br J Pharmacol (1999) 127: 252-8 [PMID:10369480]
α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb - - 6.5 pKi - - - J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470];
Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 7.5 pKi - - - J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470];
Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 8 pKi - - - J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470];
Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]