ustekinumab   Click here for help

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20
Approved drug Immunopharmacology Ligand
ustekinumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyClinical PhaseIndications
ustekinumab-auub; ABP 654Wezlana; WezenlaAmgenApproved (2023 FDA, 2024 EMA)As per reference agent; Interchangeable with reference agent
ustekinumab-aekn; AVT04Selarsdi; UzpruvoAlvotech/Teva Pharmaceuticals/STADA ArzneimittelApproved (2024 FDA & EMA)As per reference agent
ustekinumab-ttwe; SB17Pyzchiva; EpyztekSandoz/Samsung BioepisApproved (2024 FDA, EMA and S Korea MFDS)As per reference agent; Interchangeable with reference agent*
ustekinumab; CT-P43SteQeymaCelltrionApproved (2024 EMA)As per reference agent
ustekinumab-aauz; FYB202Otulfi Fresenius Kabi/Formycon Approved (2024 EMA & FDA)As per reference agent; available as subcutaneous and intravenous formulations

*After expiry of the period of exclusivity for the first interchangeable biosimilar product.
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2009), EMA (2009))
International Nonproprietary Names Click here for help
INN number INN
8954 ustekinumab
Synonyms Click here for help
CNTO-1275 | L04AC05 | Stelara® | TT-20
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 172
Other databases
GtoPdb PubChem SID 178103467
PubChem SID 178103467
Search PubMed clinical trials ustekinumab
Search PubMed titles ustekinumab
Search PubMed titles/abstracts ustekinumab
Wikipedia Ustekinumab