ustekinumab   Click here for help

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20
Approved drug Immunopharmacology Ligand
ustekinumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyClinical PhaseIndications
ustekinumab-auub; ABP 654Wezlana; WezenlaAmgenApproved (2023 FDA, 2024 EMA)As per reference agent; Interchangeable with reference agent
ustekinumab-aekn; AVT04Selarsdi; UzpruvoAlvotech/Teva Pharmaceuticals/STADA ArzneimittelApproved (2024 FDA & EMA)As per reference agent
ustekinumab-ttwe; SB17Pyzchiva; Epyztek; EksunbiSandoz/Samsung BioepisApproved (2024 FDA, EMA and S Korea MFDS)As per reference agent; Interchangeable with reference agent*
ustekinumab; CT-P43SteQeymaCelltrionApproved (2024 EMA)As per reference agent
ustekinumab-aauz; FYB202Otulfi; Fymskina Fresenius Kabi/Formycon Approved (2024 EMA & FDA)As per reference agent; available as subcutaneous and intravenous formulations
ustekinumab-srlf; DMB-3115ImuldosaAccord BioPharma/Intas PharmaceuticalsApproved (2024 FDA)As per reference agent
ustekinumab-kfce; Bmab1200Yesintek Biocon BiologicsApproved (2024 FDA)As per reference agent

*After expiry of the period of exclusivity for the first interchangeable biosimilar product.
References
1. Giles-Komar J, Knight DM, Peritt D, Scallon B, Shealy D. (2005)
Also an IL-12 anti-idiotype antibody to the antibody.
Patent number: US6902734. Assignee: Centocor, Inc.. Priority date: 07/08/2000. Publication date: 07/06/2005.
2. Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, Li K, Peyrin-Biroulet L, Van Assche G et al.. (2019)
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis.
N Engl J Med, 381 (13): 1201-1214. [PMID:31553833]