ustekinumab

Home
Ligands
ustekinumab

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20

ustekinumab is an approved drug (FDA (2009), EMA (2009))

Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:

Name	Trade name	Company	Clinical Phase	Indications
ustekinumab-auub; ABP 654	Wezlana; Wezenla	Amgen	Approved (2023 FDA, 2024 EMA)	As per reference agent; Interchangeable with reference agent
ustekinumab-aekn; AVT04	Selarsdi; Uzpruvo	Alvotech/Teva Pharmaceuticals/STADA Arzneimittel	Approved (2024 FDA & EMA)	As per reference agent
ustekinumab-ttwe; SB17	Pyzchiva; Epyztek; Eksunbi	Sandoz/Samsung Bioepis	Approved (2024 FDA, EMA and S Korea MFDS)	As per reference agent; Interchangeable with reference agent*
ustekinumab; CT-P43	SteQeyma	Celltrion	Approved (2024 EMA)	As per reference agent
ustekinumab-aauz; FYB202	Otulfi; Fymskina	Fresenius Kabi/Formycon	Approved (2024 EMA & FDA)	As per reference agent; available as subcutaneous and intravenous formulations
ustekinumab-srlf; DMB-3115	Imuldosa	Accord BioPharma/Intas Pharmaceuticals	Approved (2024 FDA)	As per reference agent
ustekinumab-kfce; Bmab1200	Yesintek	Biocon Biologics	Approved (2024 FDA)	As per reference agent

*After expiry of the period of exclusivity for the first interchangeable biosimilar product.

Classification
Compound class	Antibody
Approved drug?	Yes (FDA (2009), EMA (2009))

International Nonproprietary Names
INN number	INN
8954	ustekinumab

Synonyms
CNTO-1275 \| L04AC05 \| Stelara® \| TT-20

Synonyms

CNTO-1275 | L04AC05 | Stelara® | TT-20

Database Links
Specialist databases
IMGT/mAb-DB	172
Other databases
GtoPdb PubChem SID	178103467
PubChem SID	178103467
Search PubMed clinical trials	ustekinumab
Search PubMed titles	ustekinumab
Search PubMed titles/abstracts	ustekinumab
Wikipedia	Ustekinumab