ChEMBL ligand: CHEMBL321022
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942]
ChEMBL	Binding affinity to FKBP12 by fluorescence polarization assay	B	6.77	pIC50	170	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
GtoPdb	Binding affinity determined by a fluorescence polarization assay	-	6.94	pIC50	114	nM	IC50	J Med Chem (2012) 55: 4123-31 [PMID:22455398]
ChEMBL	Binding affinity to FKBP12 by competitive fluorescence polarization assay	B	6.94	pIC50	114	nM	IC50	J Med Chem (2012) 55: 4123-4131 [PMID:22455398]
ChEMBL	Inhibition of binding to Phe36Val (F36V) mutant of FK506 binding protein 12	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3181-3184 [PMID:12951089]
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790]
ChEMBL	Binding affinity to FKBP52 (unknown origin)	B	7.7	pKi	20	nM	Ki	J Med Chem (2016) 59: 9622-9644 [PMID:27409354]
ChEMBL	Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay	B	4.98	pIC50	10500	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
ChEMBL	Binding affinity to FKBP52 FK1 domain by competitive fluorescence polarization assay	B	5.03	pIC50	9370	nM	IC50	J Med Chem (2012) 55: 4123-4131 [PMID:22455398]
GtoPdb	Binding affinity determined by a fluorescence polarization assay	-	5.03	pIC50	9370	nM	IC50	J Med Chem (2012) 55: 4123-31 [PMID:22455398]
FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451]
ChEMBL	Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay	B	5.08	pIC50	8360	nM	IC50	J Med Chem (2012) 55: 4114-4122 [PMID:22455444]
GtoPdb	Binding affinity determined by a fluorescence polarization assay	-	5.2	pIC50	6300	nM	IC50	J Med Chem (2012) 55: 4123-31 [PMID:22455398]
ChEMBL	Binding affinity to FKBP51 FK1 domain by competitive fluorescence polarization assay	B	5.2	pIC50	6300	nM	IC50	J Med Chem (2012) 55: 4123-4131 [PMID:22455398]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]