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ChEMBL ligand: CHEMBL219410 (ABT-578, Mdt-4107, Zotarolimus) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
ChEMBL | Inhibitory activity against FKBP12 | B | 8.48 | pIC50 | 3.3 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5340-5343 [PMID:16185865] |
FKBP prolyl isomerase 1A in Human [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
GtoPdb | - | - | 8.55 | pIC50 | 2.8 | nM | IC50 | Eur Heart J (2006) 27: 988-93 [PMID:16449248] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]