ATPO [Ligand Id: 4141] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL265301
1 CHEMBL265301_lig_chart_1 Glutamate NMDA receptor Rat
There should be some charts here, you may need to enable JavaScript!
2 CHEMBL265301_lig_chart_2 Glutamate receptor ionotropic, AMPA Rat
There should be some charts here, you may need to enable JavaScript!
3 CHEMBL265301_lig_chart_3 Glutamate receptor ionotropic, kainate Rat
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455456457458459461460] [UniProtKB: P35439Q00959Q00960Q00961Q62645Q8VHN2Q9R1M7]
ChEMBL In vitro inhibition of [3H]CPP binding to NMDA receptor. B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1996) 39: 1682-1691 [PMID:8648608]
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444445446447] [UniProtKB: P19490P19491P19492P19493]
ChEMBL In vitro inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA. B 4.46 pIC50 35000 nM IC50 J. Med. Chem. (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL Inhibition of AMPA induced electrophysiological responses in rat cortical slices. F 4.55 pIC50 28000 nM IC50 J. Med. Chem. (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL In vitro inhibition of [3H]CNQX binding to Ionotropic glutamate receptor AMPA. B 5.24 pIC50 5700 nM IC50 J. Med. Chem. (1996) 39: 1682-1691 [PMID:8648608]
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450451452453454] [UniProtKB: P22756P42260P42264Q01812Q63273]
ChEMBL In vitro inhibition of [3H]KAIN binding to Ionotropic glutamate receptor kainate. B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1996) 39: 1682-1691 [PMID:8648608]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]