ATPO [Ligand Id: 4141] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL265301
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL In vitro inhibition of [3H]CPP binding to NMDA receptor. B 4 pIC50 >100000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493]
ChEMBL In vitro inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA. B 4.46 pIC50 35000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL Inhibition of AMPA induced electrophysiological responses in rat cortical slices. F 4.55 pIC50 28000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL In vitro inhibition of [3H]CNQX binding to Ionotropic glutamate receptor AMPA. B 5.24 pIC50 5700 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450, 451, 452, 453, 454] [UniProtKB: P22756, P42260, P42264, Q01812, Q63273]
ChEMBL In vitro inhibition of [3H]KAIN binding to Ionotropic glutamate receptor kainate. B 4 pIC50 >100000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]