S(+)-apomorphine [Ligand Id: 8285] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL416288 (S-(+)-apomorphine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand | B | 5.53 | pKi | 2980 | nM | Ki | J Med Chem (1990) 33: 1800-1805 [PMID:1971309] |
| ChEMBL | In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement. | B | 5.44 | pIC50 | 3620 | nM | IC50 | J Med Chem (1990) 33: 600-607 [PMID:2405158] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Binding affinity at rat striatal Dopamine receptor D2 using [3H]- piperone radioligand | B | 7.23 | pKi | 58.3 | nM | Ki | J Med Chem (1990) 33: 1800-1805 [PMID:1971309] |
| ChEMBL | In vitro binding affinity towards rat Dopamine receptor D2 by [3H]spiperone displacement. | B | 6.17 | pIC50 | 680 | nM | IC50 | J Med Chem (1990) 33: 600-607 [PMID:2405158] |
| MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987] | ||||||||
| ChEMBL | Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization assay | B | 6.76 | pIC50 | 175 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2571-2574 [PMID:28400230] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against erythrocytic stage Plasmodium falciparum in human RBC assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2021) 64: 1763-1785 [PMID:33534577] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
