mibolerone [Ligand Id: 2859] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL425863 (Cheque drops, Dihydrolone, Matenon, Mibolerone, Mibolerone ciii, NSC-72260, U-10,997, U-10-997, U-10997) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Androgen receptor in Human [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 | J Clin Endocrinol Metab (2000) 85: 2253-9 [PMID:10852459] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate | B | 9.12 | pKi | 0.76 | nM | Ki | J Med Chem (2005) 48: 917-925 [PMID:15715462] |
| ChEMBL | Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1045-1047 [PMID:11327585] |
| ChEMBL | Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone | B | 9.12 | pKi | 0.75 | nM | Ki | J Med Chem (2000) 43: 3344-3347 [PMID:10966753] |
| ChEMBL | Inhibition of rat prostate cytosolic androgen receptor | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5285-5288 [PMID:15454212] |
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 8.78 | pIC50 | 1.66 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| GtoPdb | - | - | 8.8 | pIC50 | - | - | - | Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775] |
| ChEMBL | Displacement of [3H]-MIB from rat prostate cytosolic androgen receptor by liquid scintillation counting method | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2017) 25: 1600-1607 [PMID:28174065] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
