ChEMBL ligand: CHEMBL180650
5-lipoxygenase activating protein in Human [ChEMBL: CHEMBL4550] [UniProtKB: P20292] There should be some charts here, you may need to enable JavaScript!
mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] There should be some charts here, you may need to enable JavaScript!
mPGES2/Prostaglandin E synthase 2 in Human [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292]
ChEMBL	In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of FLAP	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
ChEMBL	Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis	B	6.02	pIC50	960	nM	IC50	J Med Chem (2015) 58: 4727-4737 [PMID:25961169]
ChEMBL	Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis	B	7.64	pIC50	23	nM	IC50	J Med Chem (2015) 58: 4727-4737 [PMID:25961169]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724]
ChEMBL	Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay	B	8.52	pIC50	3	nM	IC50	J Med Chem (2011) 54: 3163-3174 [PMID:21466167]
mPGES2/Prostaglandin E synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724]
ChEMBL	In vitro inhibition against recombinant human mPGES-2	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of human mPGES2	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174]
ChEMBL	Inhibition of mPGES2	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
ChEMBL	Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of TX synthase	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
ChEMBL	In vitro inhibition against human Thromboxane synthase	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of TX synthase	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]