Synonyms: INCB-053914 | INCB053914
Compound class:
Synthetic organic
Comment: Uzansertib (INCB053914) is a pan-PIM kinase inhibitor that was developed by Incyte Corporation as a novel anticancer agent [1]. The chemical structure that was submitted to the WHO for the INN uzansertib is identical to the structure of INCB053914. INCB053914 is a Type 1, ATP-competitive inhibitor. The PIMs (PIM1, PIM2, and PIM3) are serine/threonine protein kinases that are important players in JAK/STAT and PI3K/AKT signalling pathways and in tumourigenesis. PIMs are known to be overexpressed in haematologic and solid tumours, and consequently PIM inhibitors are being developed and investigated for clinical anti-tumour potential.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
International Nonproprietary Names ![]() |
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INN number | INN |
11257 | uzansertib |
Synonyms ![]() |
INCB-053914 | INCB053914 |
Database Links ![]() |
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CAS Registry No. | 1620012-39-6 (source: WHO INN record) |
GtoPdb PubChem SID | 404859073 |
PubChem CID | 129606875 |
Search Google for chemical match using the InChIKey | PTORCEYGCGXHDH-SGQXWQAPSA-N |
Search Google for chemicals with the same backbone | PTORCEYGCGXHDH |
Search PubMed clinical trials | uzansertib |
Search PubMed titles | uzansertib |
Search PubMed titles/abstracts | uzansertib |
UniChem Compound Search for chemical match using the InChIKey | PTORCEYGCGXHDH-SGQXWQAPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PTORCEYGCGXHDH-SGQXWQAPSA-N |