ChEMBL ligand: CHEMBL487805
5-HT7 receptor/5-hydroxytryptamine receptor 7 in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] There should be some charts here, you may need to enable JavaScript!
ABCB1/ATP-dependent translocase ABCB1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/METTL3/METTL14 in Human [ChEMBL: CHEMBL4106140] [GtoPdb: 3181] [UniProtKB: Q86U44, Q9HCE5] There should be some charts here, you may need to enable JavaScript!
Neuraminidase in Influenza A virus [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT7 receptor/5-hydroxytryptamine receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	B	4.2	pIC50	63400	nM	IC50	J Nat Prod (2003) 66: 535-537 [PMID:12713409]
ABCB1/ATP-dependent translocase ABCB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of human recombinant P-gp ATPase activity in isolated membranes incubated in presence of verapamil by firefly luciferase based luminescence analysis	B	4.71	pIC50	19710	nM	IC50	RSC Med Chem (2024) 15: 720-732 [PMID:38389870]
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/METTL3/METTL14 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106140] [GtoPdb: 3181] [UniProtKB: Q86U44, Q9HCE5]
ChEMBL	Inhibition of METTL3/METTL14 (unknown origin) using SAM and 5'-GGACUGGACUGGACUGGACU-3' as substrates incubated for 2 hrs by LC-MS/MS analysis	B	4.7	pIC50	19930	nM	IC50	ACS Med Chem Lett (2024) 15: 1491-1499 [PMID:39291017]
ChEMBL	Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using (5'P-UACACUCGAUCUGGACUAAAGCUGCUC-3') as substrate pre-treated for 60 mins followed by substrate addition and measured for 1 hr by RapidFire mass spectrometry analysis	B	4.7	pIC50	19900	nM	IC50	Eur J Med Chem (2024) 274: 116526-116526 [PMID:38805939]
ChEMBL	Inhibition of METTL3/METTL14 (unknown origin) using RNA 5'-GGACUGGACUGGACU-3' as substrate incubated for 2 hrs by LC-MS/MS analysis	B	4.72	pIC50	19230	nM	IC50	J Med Chem (2023) 66: 1654-1677 [PMID:36692498]
Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0]
ChEMBL	Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay	B	4.22	pIC50	59900	nM	IC50	Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042]
ChEMBL	Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay	B	4.3	pIC50	50600	nM	IC50	Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042]
ChEMBL	Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay	B	4.33	pIC50	47300	nM	IC50	Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]