combretastatin A4 [Ligand Id: 8854] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL67 (2'-deoxycombretastatin a1, Combrestatin a4, Combretastatin 4, Combretastatin a-4, Combretastatin a4, NSC-613729, NSC-817373)
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • programmed cell death 1 (CD279)/Programmed cell death protein 1/Programmed cell death 1 ligand 1 in Human [ChEMBL: CHEMBL4523993] [GtoPdb: 2760] [UniProtKB: Q15116, Q9NZQ7]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
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  • OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956]
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  • tubulin beta 3 class III/Tubulin beta-3 chain in Human [ChEMBL: CHEMBL2597] [GtoPdb: 2752] [UniProtKB: Q13509]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta tubulin in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3186] [UniProtKB: Q25270]
ChEMBL Concentration required to inhibit tubulin polymerization at 10 uM F 5.7 pIC50 2000 nM IC50 Bioorg Med Chem Lett (2005) 15: 4048-4052 [PMID:16005627]
ChEMBL Inhibition of tubulin polymerization interacting at the colchicine binding site. F 5.72 pIC50 1900 nM IC50 Bioorg Med Chem Lett (2005) 15: 1051-1054 [PMID:15686910]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis B 5 pIC50 >10000 nM IC50 J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of FGFR1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis B 5 pIC50 >10000 nM IC50 J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay B 7.94 pIC50 11.5 nM IC50 Bioorg Med Chem (2013) 21: 891-902 [PMID:23332369]
ChEMBL Inhibition of p-gp overexpressed in human SKOV3/M6-6 isogenic cells after 48 hrs by sulforhodamine B assay B 8.18 pIC50 6.6 nM IC50 J Med Chem (2013) 56: 6829-6844 [PMID:23895532]
programmed cell death 1 (CD279)/Programmed cell death protein 1/Programmed cell death 1 ligand 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523993] [GtoPdb: 2760] [UniProtKB: Q15116, Q9NZQ7]
ChEMBL Inhibition of PD1/PDL1 (unknown origin) protein-protein interaction measured after 15 mins by HTRF assay B 4 pIC50 >100000 nM IC50 Eur J Med Chem (2021) 213: 113058-113058 [PMID:33280898]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL Inhibition of human OCT2 expressed in HEK293 cells assessed as Asp+ uptake after 10 mins by fluorescence assay B 4.21 pIC50 61940 nM IC50 Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL Inhibition of human OAT1 expressed in HEK293 cells assessed as 6-CF uptake after 5 mins by fluorescence assay B 4.38 pIC50 41360 nM IC50 Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL Inhibition of human OAT3 expressed in HEK293 cells assessed as 6-CF uptake after 5 mins by fluorescence assay B 4.79 pIC50 16390 nM IC50 Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956]
ChEMBL Inhibition of human OATP2B1 expressed in HEK293 cells assessed as DBF uptake after 5 mins by fluorescence assay B 4.91 pIC50 12270 nM IC50 Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7]
ChEMBL Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) after 2 hrs by scintillation proximity assay B 6.92 pKi 120 nM Ki J Med Chem (2013) 56: 8008-8018 [PMID:24106982]
ChEMBL Displacement of [3H]colchicine from tubulin B 8.52 pKi 3 nM Ki Bioorg Med Chem Lett (2005) 15: 5154-5159 [PMID:16198562]
ChEMBL Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry B 5.05 pIC50 9000 nM IC50 Medchemcomm (2014) 5: 766-782
ChEMBL Inhibition of tubulin polymerization B 5.24 pIC50 5800 nM IC50 J Med Chem (2007) 50: 749-754 [PMID:17249649]
ChEMBL Inhibition of tubulin polymerization F 5.31 pIC50 4920 nM IC50 J Med Chem (2006) 49: 3143-3152 [PMID:16722633]
ChEMBL Inhibition of tubulin polymerization (unknown origin) measured after 1 min by fluorescence assay B 5.37 pIC50 4300 nM IC50 Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126]
ChEMBL Inhibition of tubulin (unknown origin) polymerization measured every 1 min over 20 mins by fluorescence assay B 5.37 pIC50 4220 nM IC50 Bioorg Med Chem Lett (2021) 38: 127880-127880 [PMID:33636303]
ChEMBL Inhibition of tubulin polymerization (unknown origin) measured afer 30 mins every 1 min for 20 mins by spectrophotometric method B 5.37 pIC50 4220 nM IC50 Eur J Med Chem (2021) 220: 113449-113449 [PMID:33895499]
ChEMBL Inhibition of tubulin (unknown origin) polymerization B 5.37 pIC50 4220 nM IC50 Bioorg Med Chem Lett (2019) 29: 22-27 [PMID:30448234]
ChEMBL Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells B 5.4 pIC50 3981.07 nM IC50 Med Chem Res (2013) 22: 3229-3241
ChEMBL Inhibition of tubulin (unknown origin) polymerization measured for 60 mins B 5.57 pIC50 2700 nM IC50 Eur J Med Chem (2013) 68: 222-232 [PMID:23981529]
ChEMBL Inhibition of tubulin polymerization (unknown origin) assessed as microtubule assembly preincubated for 30 mins by microplate based assay B 5.6 pIC50 2500 nM IC50 Eur J Med Chem (2021) 209: 112873-112873 [PMID:33038796]
ChEMBL Inhibition of tubulin (unknown origin) polymerization by spectrophotometry B 5.6 pIC50 2500 nM IC50 Bioorg Med Chem (2014) 22: 4917-4923 [PMID:25059503]
ChEMBL Inhibition of tubulin polymerization B 5.66 pIC50 2200 nM IC50 J Med Chem (2007) 50: 2865-2874 [PMID:17497841]
ChEMBL Inhibition of tubulin polymerization B 5.66 pIC50 2200 nM IC50 J Med Chem (2004) 47: 6120-6123 [PMID:15566282]
ChEMBL Inhibition of tubulin polymerization (unknown origin) in presence of GTP measured after 60 mins by spectrophotometric method B 5.66 pIC50 2170 nM IC50 Eur J Med Chem (2019) 173: 1-14 [PMID:30981112]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 5.68 pIC50 2100 nM IC50 Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL Inhibition of tubulin polymerization F 5.68 pIC50 2100 nM IC50 Bioorg Med Chem Lett (2006) 16: 1191-1196 [PMID:16377187]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 5.7 pIC50 2000 nM IC50 Medchemcomm (2010) 1: 183-198
ChEMBL Inhibition of tubulin polymerization (unknown origin) after 30 mins B 5.74 pIC50 1800 nM IC50 Medchemcomm (2010) 1: 183-198
ChEMBL Inhibition of tubulin (unknown origin) polymerization after 1 hr by multiplate reader method B 5.76 pIC50 1730 nM IC50 Eur J Med Chem (2015) 89: 733-742 [PMID:25462279]
ChEMBL Inhibition of tubulin polymerization B 5.77 pIC50 1700 nM IC50 J Med Chem (2006) 49: 2357-2360 [PMID:16570932]
ChEMBL Inhibition of tubulin polymerization in human A549 cells assessed as decrease in polymerized fraction of tubulin content after 48 hrs by western blot analysis B 5.79 pIC50 1620 nM IC50 Bioorg Med Chem Lett (2020) 30: 127592-127592 [PMID:33010448]
ChEMBL Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis B 5.82 pIC50 1500 nM IC50 Eur J Med Chem (2011) 46: 1343-1347 [PMID:21342735]
ChEMBL Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis B 5.82 pIC50 1500 nM IC50 Eur J Med Chem (2011) 46: 1343-1347 [PMID:21342735]
ChEMBL Inhibition of tubulin polymerization F 5.85 pIC50 1400 nM IC50 J Med Chem (2006) 49: 6425-6428 [PMID:17034150]
ChEMBL Inhibition of tubulin polymerization F 5.85 pIC50 1400 nM IC50 J Med Chem (2006) 49: 6412-6415 [PMID:17034147]
ChEMBL Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins B 5.89 pIC50 1300 nM IC50 J Med Chem (2007) 50: 4548-4552 [PMID:17685504]
ChEMBL Inhibition of tubulin (unknown origin) polymerization by fluorescence assay B 5.89 pIC50 1300 nM IC50 J Med Chem (2015) 58: 1345-1357 [PMID:25584687]
ChEMBL Inhibition of tubulin polymerization (unknown origin) assessed as fluorescence intensity measured for 90 mins by DAPI based microplate reader F 5.91 pIC50 1240 nM IC50 Eur J Med Chem (2021) 223: 113629-113629 [PMID:34175541]
ChEMBL Inhibition of tubulin polymerization B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2007) 17: 6316-6320 [PMID:17889536]
ChEMBL Inhibition of tubulin polymerization F 5.92 pIC50 1200 nM IC50 J Med Chem (2006) 49: 6656-6659 [PMID:17154496]
ChEMBL Inhibition of tubulin assembly (unknown origin) pre-incubated with compound for 15 mins before GTP addition measured after 20 mins at 30 degC post GTP addition by turbidimetry B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem (2013) 21: 632-642 [PMID:23274123]
ChEMBL Inhibition of tubulin (unknown origin) assembly after 20 mins by turbidimetric analysis B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2013) 23: 1262-1268 [PMID:23385208]
ChEMBL Inhibition of tubulin (unknown origin) polymerization after 20 mins B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2013) 23: 4669-4673 [PMID:23810282]
ChEMBL Inhibition of tubulin (unknown origin) polymerization after 1 hr by spectrophotometry B 5.92 pIC50 1200 nM IC50 Eur J Med Chem (2014) 85: 648-660 [PMID:25128667]
ChEMBL Inhibition of tubulin (unknown origin) assembly pre-incubated for 15 mins before GTP addition measured after 20 mins by turbidimetry B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem (2015) 23: 5740-5747 [PMID:26242242]
ChEMBL Inhibition of tubulin (unknown origin) polymerization after 1 hr by ELISA plate reader analysis B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem (2015) 23: 7165-7180 [PMID:26515041]
ChEMBL Inhibition of tubulin polymerization (unknown origin) by spectrophotometric method B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2019) 29: 2638-2645 [PMID:31400938]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2021) 51: 128355-128355 [PMID:34508844]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2015) 25: 1982-1985 [PMID:25817588]
ChEMBL Inhibition of tubulin (unknown origin) polymerization incubated for 1 hr by fluorescence assay B 5.97 pIC50 1080 nM IC50 Bioorg Med Chem (2014) 22: 5155-5167 [PMID:25192811]
ChEMBL Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidimetric analysis B 5.99 pIC50 1020 nM IC50 Bioorg Med Chem Lett (2018) 28: 2490-2492 [PMID:29903663]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 6 pIC50 1000 nM IC50 Eur J Med Chem (2013) 62: 28-39 [PMID:23353744]
ChEMBL Inhibition of tubulin (unknown origin) assembly preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric analysis B 6 pIC50 1000 nM IC50 J Med Chem (2015) 58: 5789-5807 [PMID:26132075]
ChEMBL Inhibition of tubulin polymerization (unknown origin) preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric method B 6 pIC50 1000 nM IC50 Eur J Med Chem (2018) 152: 283-297 [PMID:29730191]
ChEMBL Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins by spectrophotometry B 6 pIC50 1000 nM IC50 J Med Chem (2013) 56: 123-149 [PMID:23214452]
ChEMBL Inhibition of tubulin polymerization F 6 pIC50 1000 nM IC50 J Med Chem (1993) 36: 1146-1156 [PMID:8387598]
ChEMBL Inhibition of tubulin (unknown origin) polymerization incubated 15 mins prior to GTP addition by spectrophotometry B 6 pIC50 1000 nM IC50 J Med Chem (2014) 57: 6531-6552 [PMID:25025991]
ChEMBL Inhibition of tubulin (unknown origin) polymerization incubated for 15 mins prior to GTP addition measured after 20 mins by turbidimetry B 6.02 pIC50 960 nM IC50 J Med Chem (2014) 57: 1390-1402 [PMID:24502232]
ChEMBL Inhibition of tubulin assembly (unknown origin) preincubated for 15 mins followed by GTP addition measured after 20 mins by turbidimetric analysis B 6.02 pIC50 960 nM IC50 Eur J Med Chem (2013) 67: 196-207 [PMID:23867604]
ChEMBL Inhibition of tubulin (unknown origin) polymerization incubated for 90 mins by fluorescence-based assay B 6.04 pIC50 920 nM IC50 Eur J Med Chem (2021) 214: 113229-113229 [PMID:33550186]
ChEMBL Inhibition of tubulin (unknown origin) polymerization pre-incubated for 1 min measured for 1 min interval for 90 mins by fluorescence based assay B 6.04 pIC50 920 nM IC50 Medchemcomm (2015) 6: 971-976
ChEMBL Inhibition of tubulin polymerization B 6.09 pIC50 810 nM IC50 Bioorg Med Chem Lett (2007) 17: 869-873 [PMID:17174089]
ChEMBL Inhibition of tubulin polymerization (unknown origin) assessed as reduction in tubulin assembly preincubated for 15 mins followed by GTP addition by spectrophotometric method B 6.27 pIC50 540 nM IC50 Eur J Med Chem (2021) 221: 113532-113532 [PMID:34052717]
ChEMBL Inhibition of tubulin assembly (unknown origin) B 6.27 pIC50 540 nM IC50 Bioorg Med Chem Lett (2021) 41: 127923-127923 [PMID:33705908]
ChEMBL Inhibition of tubulin polymerization (unknown origin) B 6.3 pIC50 500 nM IC50 Medchemcomm (2012) 3: 1356-1372
ChEMBL Inhibition of tubulin (unknown origin) assessed as inhibition of GTP-induced polymerization incubated for 45 mins prior to GTP-addition measured after 2 hrs by DAPI-staining based fluorimetric analysis B 6.52 pIC50 300 nM IC50 Bioorg Med Chem (2013) 21: 1357-1366 [PMID:23369686]
ChEMBL Displacement of [3H]colchicine from tubulin at 65 nM B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (2006) 16: 1191-1196 [PMID:16377187]
ChEMBL Inhibition of colchicine binding to tubulin (unknown origin) B 7.64 pIC50 23 nM IC50 Eur J Med Chem (2015) 89: 733-742 [PMID:25462279]
ChEMBL Displacement of [3H]colchicine from tubulin by scintillation proximity assay B 7.89 pIC50 12.9 nM IC50 J Med Chem (2006) 49: 3143-3152 [PMID:16722633]
GtoPdb Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay. - 8.24 pIC50 5.7 nM IC50 J Med Chem (2013) 56: 6829-44 [PMID:23895532]
ChEMBL Induction of microtubule depolymerization in human A10 cells incubated for 18 hrs by indirect immunofluorescence analysis B 8.01 pEC50 9.8 nM EC50 J Med Chem (2016) 59: 5752-5765 [PMID:27213719]
ChEMBL Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis B 8.05 pEC50 9 nM EC50 Bioorg Med Chem Lett (2016) 26: 174-180 [PMID:26602281]
Tubulin in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3]
ChEMBL Inhibition of bovine brain tubulin polymerization after 30 mins B 5.31 pIC50 4900 nM IC50 Bioorg Med Chem (2015) 23: 4230-4236 [PMID:26160020]
ChEMBL Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration F 5.72 pIC50 1900 nM IC50 J Med Chem (2003) 46: 1670-1682 [PMID:12699385]
ChEMBL Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetrically B 5.74 pIC50 1800 nM IC50 Eur J Med Chem (2015) 99: 125-137 [PMID:26070164]
ChEMBL Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis B 5.92 pIC50 1200 nM IC50 J Med Chem (2015) 58: 7991-8010 [PMID:26418966]
Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550]
ChEMBL Evaluated for the inhibitory concentration against porcine brain tubulin polymerization F 5.41 pIC50 3900 nM IC50 Bioorg Med Chem Lett (1994) 4: 699-704
ChEMBL Compound was evaluated for inhibition of tubulin polymerization F 5.68 pIC50 2100 nM IC50 Bioorg Med Chem Lett (2001) 11: 2341-2343 [PMID:11527727]
ChEMBL Antitubulin activity against tubulin polymerization B 5.92 pIC50 1200 nM IC50 J Med Chem (1999) 42: 5475-5481 [PMID:10639289]
ChEMBL Concentration required to inhibit polymerization of tubulin F 5.92 pIC50 1200 nM IC50 Bioorg Med Chem Lett (2001) 11: 871-874 [PMID:11294380]
ChEMBL Inhibition of tubulin polymerization F 6 pIC50 1000 nM IC50 J Med Chem (2000) 43: 2731-2737 [PMID:10893310]
ChEMBL Inhibition of tubulin polymerization (ITP) B 6.28 pIC50 530 nM IC50 J Med Chem (2001) 44: 3932-3936 [PMID:11689079]
Tubulin beta-1 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1915] [UniProtKB: Q9H4B7]
ChEMBL Inhibition of tubulin polymerization B 5.69 pIC50 2030 nM IC50 J Med Chem (2004) 47: 4247-4257 [PMID:15293996]
ChEMBL Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree C B 5.92 pIC50 1200 nM IC50 J Med Chem (2005) 48: 4087-4099 [PMID:15943482]
ChEMBL Concentration required for 50% inhibition of tubulin polymerization B 6.74 pIC50 180 nM IC50 J Med Chem (2005) 48: 457-465 [PMID:15658859]
tubulin beta 3 class III/Tubulin beta-3 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2597] [GtoPdb: 2752] [UniProtKB: Q13509]
GtoPdb Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay. - 8.24 pIC50 5.7 nM IC50 J Med Chem (2013) 56: 6829-44 [PMID:23895532]
ChEMBL Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay B 8.24 pIC50 5.7 nM IC50 J Med Chem (2013) 56: 6829-6844 [PMID:23895532]
ChEMBL Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB method B 8.24 pIC50 5.7 nM IC50 Bioorg Med Chem (2021) 29: 115887-115887 [PMID:33310545]
ChEMBL Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay B 8.28 pIC50 5.2 nM IC50 Bioorg Med Chem (2013) 21: 891-902 [PMID:23332369]
Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856]
ChEMBL Binding constant at colchicine site of bovine brain tubulin B 6.74 pKi 180 nM Ki Bioorg Med Chem Lett (2002) 12: 465-469 [PMID:11814821]
ChEMBL Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tubulin concentration B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (1993) 3: 565-570
ChEMBL Concentration needed to inhibit tubulin polymerization by 50% F 5.92 pIC50 1200 nM IC50 J Med Chem (2002) 45: 1697-1711 [PMID:11931625]
ChEMBL Inhibition of tubulin polymerization F 6.28 pIC50 530 nM IC50 J Med Chem (1994) 37: 1126-1135 [PMID:8164254]
ChEMBL Inhibition of bovine tubulin polymerization F 6.28 pIC50 530 nM IC50 J Med Chem (1997) 40: 2266-2275 [PMID:9216846]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of Abl1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis B 5 pIC50 >10000 nM IC50 J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of Src (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis B 5 pIC50 >10000 nM IC50 J Med Chem (2014) 57: 4598-4605 [PMID:24801610]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]