ChEMBL ligand: CHEMBL67 (2'-deoxycombretastatin a1, Combrestatin a4, Combretastatin 4, Combretastatin a-4, Combretastatin a4, NSC-613729, NSC-817373)
Beta tubulin in Leishmania donovani [ChEMBL: CHEMBL3186] [UniProtKB: Q25270] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
programmed cell death 1 (CD279)/Programmed cell death protein 1/Programmed cell death 1 ligand 1 in Human [ChEMBL: CHEMBL4523993] [GtoPdb: 2760] [UniProtKB: Q15116, Q9NZQ7] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] There should be some charts here, you may need to enable JavaScript!
OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956] There should be some charts here, you may need to enable JavaScript!
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] Tubulin in Bovine [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3] There should be some charts here, you may need to enable JavaScript!
Tubulin alpha chain in Pig [ChEMBL: CHEMBL3658] [UniProtKB: P02550] There should be some charts here, you may need to enable JavaScript!
Tubulin beta-1 chain in Human [ChEMBL: CHEMBL1915] [UniProtKB: Q9H4B7] There should be some charts here, you may need to enable JavaScript!
tubulin beta 3 class III/Tubulin beta-3 chain in Human [ChEMBL: CHEMBL2597] [GtoPdb: 2752] [UniProtKB: Q13509] There should be some charts here, you may need to enable JavaScript!
Tubulin beta chain in Bovine [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta tubulin in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3186] [UniProtKB: Q25270]
ChEMBL	Concentration required to inhibit tubulin polymerization at 10 uM	F	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 4048-4052 [PMID:16005627]
ChEMBL	Inhibition of tubulin polymerization interacting at the colchicine binding site.	F	5.72	pIC50	1900	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1051-1054 [PMID:15686910]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibition of FGFR1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay	B	7.94	pIC50	11.5	nM	IC50	Bioorg Med Chem (2013) 21: 891-902 [PMID:23332369]
ChEMBL	Inhibition of p-gp overexpressed in human SKOV3/M6-6 isogenic cells after 48 hrs by sulforhodamine B assay	B	8.18	pIC50	6.6	nM	IC50	J Med Chem (2013) 56: 6829-6844 [PMID:23895532]
programmed cell death 1 (CD279)/Programmed cell death protein 1/Programmed cell death 1 ligand 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523993] [GtoPdb: 2760] [UniProtKB: Q15116, Q9NZQ7]
ChEMBL	Inhibition of PD1/PDL1 (unknown origin) protein-protein interaction measured after 15 mins by HTRF assay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2021) 213: 113058-113058 [PMID:33280898]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	Inhibition of human OCT2 expressed in HEK293 cells assessed as Asp+ uptake after 10 mins by fluorescence assay	B	4.21	pIC50	61940	nM	IC50	Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL	Inhibition of human OAT1 expressed in HEK293 cells assessed as 6-CF uptake after 5 mins by fluorescence assay	B	4.38	pIC50	41360	nM	IC50	Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	Inhibition of human OAT3 expressed in HEK293 cells assessed as 6-CF uptake after 5 mins by fluorescence assay	B	4.79	pIC50	16390	nM	IC50	Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956]
ChEMBL	Inhibition of human OATP2B1 expressed in HEK293 cells assessed as DBF uptake after 5 mins by fluorescence assay	B	4.91	pIC50	12270	nM	IC50	Medchemcomm (2017) 8: 1542-1552 [PMID:30108866]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7]
ChEMBL	Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) after 2 hrs by scintillation proximity assay	B	6.92	pKi	120	nM	Ki	J Med Chem (2013) 56: 8008-8018 [PMID:24106982]
ChEMBL	Displacement of [3H]colchicine from tubulin	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5154-5159 [PMID:16198562]
ChEMBL	Inhibition of tubulin polymerization in HEK293T cell lysate after 15 mins by spectrophotometry	B	5.05	pIC50	9000	nM	IC50	Medchemcomm (2014) 5: 766-782
ChEMBL	Inhibition of tubulin polymerization	B	5.24	pIC50	5800	nM	IC50	J Med Chem (2007) 50: 749-754 [PMID:17249649]
ChEMBL	Inhibition of tubulin polymerization	F	5.31	pIC50	4920	nM	IC50	J Med Chem (2006) 49: 3143-3152 [PMID:16722633]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) measured after 1 min by fluorescence assay	B	5.37	pIC50	4300	nM	IC50	Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization	B	5.37	pIC50	4220	nM	IC50	Bioorg Med Chem Lett (2019) 29: 22-27 [PMID:30448234]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization measured every 1 min over 20 mins by fluorescence assay	B	5.37	pIC50	4220	nM	IC50	Bioorg Med Chem Lett (2021) 38: 127880-127880 [PMID:33636303]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) measured afer 30 mins every 1 min for 20 mins by spectrophotometric method	B	5.37	pIC50	4220	nM	IC50	Eur J Med Chem (2021) 220: 113449-113449 [PMID:33895499]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) measured every minute for 20 mins by fluorescence based assay	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (2022) 66: 128721-128721 [PMID:35398303]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) incubated for 0.5 hrs in presence of GTP by spectrophotometer analysis	B	5.38	pIC50	4200	nM	IC50	Eur J Med Chem (2022) 244: 114864-114864 [PMID:36334455]
ChEMBL	Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells	B	5.4	pIC50	3981.07	nM	IC50	Med Chem Res (2013) 22: 3229-3241
ChEMBL	Inhibition of tubulin (unknown origin) polymerization measured for 60 mins	B	5.57	pIC50	2700	nM	IC50	Eur J Med Chem (2013) 68: 222-232 [PMID:23981529]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) assessed as microtubule assembly preincubated for 30 mins by microplate based assay	B	5.6	pIC50	2500	nM	IC50	Eur J Med Chem (2021) 209: 112873-112873 [PMID:33038796]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization by spectrophotometry	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem (2014) 22: 4917-4923 [PMID:25059503]
ChEMBL	Inhibition of tubulin polymerization	B	5.66	pIC50	2200	nM	IC50	J Med Chem (2004) 47: 6120-6123 [PMID:15566282]
ChEMBL	Inhibition of tubulin polymerization	B	5.66	pIC50	2200	nM	IC50	J Med Chem (2007) 50: 2865-2874 [PMID:17497841]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) in presence of GTP measured after 60 mins by spectrophotometric method	B	5.66	pIC50	2170	nM	IC50	Eur J Med Chem (2019) 173: 1-14 [PMID:30981112]
ChEMBL	Inhibition of tubulin polymerization	F	5.68	pIC50	2100	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1191-1196 [PMID:16377187]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.68	pIC50	2100	nM	IC50	Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL	Inhibition of [3H]colchicine binding to tubulin (unknown origin)	B	5.7	pIC50	2000	nM	IC50	Eur J Med Chem (2020) 195: 112270-112270 [PMID:32302879]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.7	pIC50	2000	nM	IC50	Medchemcomm (2010) 1: 183-198
ChEMBL	Inhibition of tubulin polymerization (unknown origin) preincubated for 15 mins followed by PEG and GTP addition measured after 30 mins by spectrophotometric method	B	5.71	pIC50	1970	nM	IC50	J Med Chem (2022) 65: 11187-11213 [PMID:35926141]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) after 30 mins	B	5.74	pIC50	1800	nM	IC50	Medchemcomm (2010) 1: 183-198
ChEMBL	Inhibition of tubulin (unknown origin) polymerization after 1 hr by multiplate reader method	B	5.76	pIC50	1730	nM	IC50	Eur J Med Chem (2015) 89: 733-742 [PMID:25462279]
ChEMBL	Inhibition of tubulin polymerization	B	5.77	pIC50	1700	nM	IC50	J Med Chem (2006) 49: 2357-2360 [PMID:16570932]
ChEMBL	Inhibition of tubulin polymerization in human A549 cells assessed as decrease in polymerized fraction of tubulin content after 48 hrs by western blot analysis	B	5.79	pIC50	1620	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127592-127592 [PMID:33010448]
ChEMBL	Inhibition of tubulin polymerization in human K562 cells by fluorometric analysis	B	5.82	pIC50	1500	nM	IC50	Eur J Med Chem (2011) 46: 1343-1347 [PMID:21342735]
ChEMBL	Inhibition of tubulin polymerization in human MCF7 cells by fluorometric analysis	B	5.82	pIC50	1500	nM	IC50	Eur J Med Chem (2011) 46: 1343-1347 [PMID:21342735]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) by fluorescence based analysis	B	5.83	pIC50	1480	nM	IC50	Eur J Med Chem (2022) 238: 114450-114450 [PMID:35576703]
ChEMBL	Inhibition of tubulin polymerization	F	5.85	pIC50	1400	nM	IC50	J Med Chem (2006) 49: 6412-6415 [PMID:17034147]
ChEMBL	Inhibition of tubulin polymerization	F	5.85	pIC50	1400	nM	IC50	J Med Chem (2006) 49: 6425-6428 [PMID:17034150]
ChEMBL	Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2007) 50: 4548-4552 [PMID:17685504]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization by fluorescence assay	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2015) 58: 1345-1357 [PMID:25584687]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) assessed as fluorescence intensity measured for 90 mins by DAPI based microplate reader	F	5.91	pIC50	1240	nM	IC50	Eur J Med Chem (2021) 223: 113629-113629 [PMID:34175541]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization after 1 hr by ELISA plate reader analysis	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2015) 23: 7165-7180 [PMID:26515041]
ChEMBL	Inhibition of tubulin polymerization	F	5.92	pIC50	1200	nM	IC50	J Med Chem (2006) 49: 6656-6659 [PMID:17154496]
ChEMBL	Inhibition of tubulin polymerization	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6316-6320 [PMID:17889536]
ChEMBL	Inhibition of tubulin assembly (unknown origin) pre-incubated with compound for 15 mins before GTP addition measured after 20 mins at 30 degC post GTP addition by turbidimetry	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2013) 21: 632-642 [PMID:23274123]
ChEMBL	Inhibition of tubulin (unknown origin) assembly after 20 mins by turbidimetric analysis	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1262-1268 [PMID:23385208]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization after 20 mins	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4669-4673 [PMID:23810282]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization after 1 hr by spectrophotometry	B	5.92	pIC50	1200	nM	IC50	Eur J Med Chem (2014) 85: 648-660 [PMID:25128667]
ChEMBL	Inhibition of tubulin (unknown origin) assembly pre-incubated for 15 mins before GTP addition measured after 20 mins by turbidimetry	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2015) 23: 5740-5747 [PMID:26242242]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) by spectrophotometric method	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2638-2645 [PMID:31400938]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128355-128355 [PMID:34508844]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1982-1985 [PMID:25817588]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization incubated for 1 hr by fluorescence assay	B	5.97	pIC50	1080	nM	IC50	Bioorg Med Chem (2014) 22: 5155-5167 [PMID:25192811]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidimetric analysis	B	5.99	pIC50	1020	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2490-2492 [PMID:29903663]
ChEMBL	Inhibition of tubulin polymerization	F	6	pIC50	1000	nM	IC50	J Med Chem (1993) 36: 1146-1156 [PMID:8387598]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization incubated 15 mins prior to GTP addition by spectrophotometry	B	6	pIC50	1000	nM	IC50	J Med Chem (2014) 57: 6531-6552 [PMID:25025991]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins by spectrophotometry	B	6	pIC50	1000	nM	IC50	J Med Chem (2013) 56: 123-149 [PMID:23214452]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	6	pIC50	1000	nM	IC50	Eur J Med Chem (2013) 62: 28-39 [PMID:23353744]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition by turbidity based spectrophotometer analysis	B	6	pIC50	1000	nM	IC50	ACS Med Chem Lett (2017) 8: 521-526 [PMID:28523104]
ChEMBL	Inhibition of tubulin (unknown origin) assembly preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric analysis	B	6	pIC50	1000	nM	IC50	J Med Chem (2015) 58: 5789-5807 [PMID:26132075]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric method	B	6	pIC50	1000	nM	IC50	Eur J Med Chem (2018) 152: 283-297 [PMID:29730191]
ChEMBL	Inhibition of tubulin assembly (unknown origin) preincubated for 15 mins followed by GTP addition measured after 20 mins by turbidimetric analysis	B	6.02	pIC50	960	nM	IC50	Eur J Med Chem (2013) 67: 196-207 [PMID:23867604]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization incubated for 15 mins prior to GTP addition measured after 20 mins by turbidimetry	B	6.02	pIC50	960	nM	IC50	J Med Chem (2014) 57: 1390-1402 [PMID:24502232]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization incubated for 90 mins by fluorescence-based assay	B	6.04	pIC50	920	nM	IC50	Eur J Med Chem (2021) 214: 113229-113229 [PMID:33550186]
ChEMBL	Inhibition of tubulin (unknown origin) polymerization pre-incubated for 1 min measured for 1 min interval for 90 mins by fluorescence based assay	B	6.04	pIC50	920	nM	IC50	Medchemcomm (2015) 6: 971-976
ChEMBL	Inhibition of tubulin polymerization	B	6.09	pIC50	810	nM	IC50	Bioorg Med Chem Lett (2007) 17: 869-873 [PMID:17174089]
ChEMBL	Inhibition of tubulin assembly (unknown origin)	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2021) 41: 127923-127923 [PMID:33705908]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) assessed as reduction in tubulin assembly preincubated for 15 mins followed by GTP addition by spectrophotometric method	B	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2021) 221: 113532-113532 [PMID:34052717]
ChEMBL	Inhibition of tubulin polymerization (unknown origin) preincubated for 15 mins followed by GTP addition and measured after 20 mins by spectrophotometer based analysis	B	6.27	pIC50	540	nM	IC50	J Med Chem (2022) 65: 15805-15818 [PMID:36395526]
ChEMBL	Inhibition of tubulin polymerization (unknown origin)	B	6.3	pIC50	500	nM	IC50	Medchemcomm (2012) 3: 1356-1372
ChEMBL	Inhibition of tubulin (unknown origin) assessed as inhibition of GTP-induced polymerization incubated for 45 mins prior to GTP-addition measured after 2 hrs by DAPI-staining based fluorimetric analysis	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2013) 21: 1357-1366 [PMID:23369686]
ChEMBL	Displacement of [3H]colchicine from tubulin at 65 nM	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1191-1196 [PMID:16377187]
ChEMBL	Inhibition of colchicine binding to tubulin (unknown origin)	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2015) 89: 733-742 [PMID:25462279]
ChEMBL	Displacement of [3H]colchicine from tubulin by scintillation proximity assay	B	7.89	pIC50	12.9	nM	IC50	J Med Chem (2006) 49: 3143-3152 [PMID:16722633]
GtoPdb	Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.	-	8.24	pIC50	5.7	nM	IC50	J Med Chem (2013) 56: 6829-44 [PMID:23895532]
ChEMBL	Inhibition of tubulin polymerization in human HeLa cells assessed as microtubule network polymerization after 30 mins by immunofluorescence analysis	B	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2022) 240: 114573-114573 [PMID:35797900]
ChEMBL	Induction of microtubule depolymerization in human A10 cells incubated for 18 hrs by indirect immunofluorescence analysis	B	8.01	pEC50	9.8	nM	EC50	J Med Chem (2016) 59: 5752-5765 [PMID:27213719]
ChEMBL	Inhibition of Tubulin polymerization in human HeLa cells assessed as decrease in dynamic tyrosinated microtubules after 2 hrs by microplate reader analysis	B	8.05	pEC50	9	nM	EC50	Bioorg Med Chem Lett (2016) 26: 174-180 [PMID:26602281]
Tubulin in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3]
ChEMBL	Inhibition of bovine brain tubulin polymerization after 30 mins	B	5.31	pIC50	4900	nM	IC50	Bioorg Med Chem (2015) 23: 4230-4236 [PMID:26160020]
ChEMBL	Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration	F	5.72	pIC50	1900	nM	IC50	J Med Chem (2003) 46: 1670-1682 [PMID:12699385]
ChEMBL	Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetrically	B	5.74	pIC50	1800	nM	IC50	Eur J Med Chem (2015) 99: 125-137 [PMID:26070164]
ChEMBL	Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2015) 58: 7991-8010 [PMID:26418966]
Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550]
ChEMBL	Evaluated for the inhibitory concentration against porcine brain tubulin polymerization	F	5.41	pIC50	3900	nM	IC50	Bioorg Med Chem Lett (1994) 4: 699-704
ChEMBL	Compound was evaluated for inhibition of tubulin polymerization	F	5.68	pIC50	2100	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2341-2343 [PMID:11527727]
ChEMBL	Antitubulin activity against tubulin polymerization	B	5.92	pIC50	1200	nM	IC50	J Med Chem (1999) 42: 5475-5481 [PMID:10639289]
ChEMBL	Concentration required to inhibit polymerization of tubulin	F	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2001) 11: 871-874 [PMID:11294380]
ChEMBL	Inhibition of tubulin polymerization	F	6	pIC50	1000	nM	IC50	J Med Chem (2000) 43: 2731-2737 [PMID:10893310]
ChEMBL	Inhibition of tubulin polymerization (ITP)	B	6.28	pIC50	530	nM	IC50	J Med Chem (2001) 44: 3932-3936 [PMID:11689079]
Tubulin beta-1 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1915] [UniProtKB: Q9H4B7]
ChEMBL	Inhibition of tubulin polymerization	B	5.69	pIC50	2030	nM	IC50	J Med Chem (2004) 47: 4247-4257 [PMID:15293996]
ChEMBL	Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree C	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2005) 48: 4087-4099 [PMID:15943482]
ChEMBL	Concentration required for 50% inhibition of tubulin polymerization	B	6.74	pIC50	180	nM	IC50	J Med Chem (2005) 48: 457-465 [PMID:15658859]
tubulin beta 3 class III/Tubulin beta-3 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2597] [GtoPdb: 2752] [UniProtKB: Q13509]
GtoPdb	Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.	-	8.24	pIC50	5.7	nM	IC50	J Med Chem (2013) 56: 6829-44 [PMID:23895532]
ChEMBL	Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay	B	8.24	pIC50	5.7	nM	IC50	J Med Chem (2013) 56: 6829-6844 [PMID:23895532]
ChEMBL	Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by SRB method	B	8.24	pIC50	5.7	nM	IC50	Bioorg Med Chem (2021) 29: 115887-115887 [PMID:33310545]
ChEMBL	Inhibition of beta-3 tubulin (unknown origin) transfected in human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem (2013) 21: 891-902 [PMID:23332369]
Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856]
ChEMBL	Binding constant at colchicine site of bovine brain tubulin	B	6.74	pKi	180	nM	Ki	Bioorg Med Chem Lett (2002) 12: 465-469 [PMID:11814821]
ChEMBL	Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tubulin concentration	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem Lett (1993) 3: 565-570
ChEMBL	Concentration needed to inhibit tubulin polymerization by 50%	F	5.92	pIC50	1200	nM	IC50	J Med Chem (2002) 45: 1697-1711 [PMID:11931625]
ChEMBL	Inhibition of tubulin polymerization	F	6.28	pIC50	530	nM	IC50	J Med Chem (1994) 37: 1126-1135 [PMID:8164254]
ChEMBL	Inhibition of bovine tubulin polymerization	F	6.28	pIC50	530	nM	IC50	J Med Chem (1997) 40: 2266-2275 [PMID:9216846]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of Abl1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 4598-4605 [PMID:24801610]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of Src (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 4598-4605 [PMID:24801610]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]